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dc.contributor.authorYildiz, Sevda
dc.contributor.authorCakarer, Sirmahan
dc.contributor.authorOzcan, Ilknur
dc.contributor.authorKeskin-Yalcin, Basak
dc.contributor.authorUnsal, Gurkan
dc.contributor.authorSoluk-Tekkesin, Merva
dc.contributor.authorAkyildiz, Servet
dc.date.accessioned2020-09-02T06:58:15Z
dc.date.available2020-09-02T06:58:15Z
dc.date.issued2018
dc.identifier.citationAkyildiz S., Soluk-Tekkesin M., Keskin-Yalcin B., Unsal G., Yildiz S., Ozcan I., Cakarer S., "Acceleration Of Fracture Healing İn Experimental Model: Platelet-Rich Fibrin Or Hyaluronic Acid?", Journal Of Cranıofacıal Surgery, Vol.29, Pp.1794-1798, 2018
dc.identifier.issn1049-2275
dc.identifier.uri10.1097/scs.0000000000004934
dc.identifier.urihttp://hdl.handle.net/20.500.12627/1033
dc.description.abstractIn this study, we compared the bone-healing effects of the local application of platelet-rich fibrin (PRF) and hyaluronic acid (HA) to bilateral tibial fractures in rats. Twenty-three adult male Sprague-Dawley rats were used. Twenty-two animals were randomly allocated to a control group (n = 6) and 2 study groups: PRF (n = 8) and HA (n = 8). The 23rd rat was used as a donor to obtain PRF. Each group was divided into 2 subgroups for histomorphometric and radiologic assessments at 2 and 6 weeks. Foreign body reaction, necrosis, inflammation, new bone formation, and fibrosis were investigated as bone healing parameters in terms of histopathologic analysis. The difference between the groups for these parameters was evaluated. The radiologic evaluation was performed by comparing the 3-dimensional reconstruction images of the fracture sites between the study and control groups. Histomorphometric evaluation showed that at 2 weeks postoperatively, the control group showed lesser bone formation (26.1 +/- 6.6%) when compared to the study (HA: 54.7 +/- 9.7%; PRF: 75.3 +/- 19.2%) groups and PRF group showed highest total ossification. At 6 weeks postoperatively the PRF group showed lesser total ossification (50.7 +/- 28.2%) when compared to control (76.3 +/- 21.7%) and HA group. The HA (88.8 +/- 13.3%) showed highest total ossification. In the control group, fibrosis was more prominent at week 6, whereas in the HA and PRF groups the amount of ossification increased. In contrast to histopathologic healing, radiologic bone healing did not differ significantly among the study and control groups 2 weeks after surgery, whereas at 6 weeks, the results of radiologic bone formation were in accordance with those of histopathologic bone healing.
dc.language.isoeng
dc.rightsAtıf 4.0 Uluslararası
dc.rights.uriinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSurgery
dc.titleAcceleration of Fracture Healing in Experimental Model: Platelet-Rich Fibrin or Hyaluronic Acid?
dc.typearticle
dc.contributor.departmentDiş Hekimliği Fakültesi,Klinik Bilimler,Ağız, Diş Ve Çene Radyolojisi
dc.contributor.authorID0000-0003-1357-6933; 0000-0001-9006-5630; 0000-0002-7178-3335
dc.identifier.volume29
dc.identifier.issue7
dc.identifier.startpage1794
dc.identifier.endpage1798


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