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dc.contributor.authorNørskov-Lauritsen, Niels
dc.contributor.authorDamar Çelik, Damla
dc.contributor.authorÖzbek Çelik, Berna
dc.date.accessioned2020-09-29T08:06:35Z
dc.date.available2020-09-29T08:06:35Z
dc.date.issued2020
dc.identifier.citationDamar Çelik D., Özbek Çelik B., Nørskov-Lauritsen ., " Post-Antibiotic Effect Of Various Antibiotics Against Achromobacter Xylosoxidans Strains Isolated From Patients With Cystic Fibrosis", J Clin Exp Invest, Vol.11, Pp.1-5, 2020
dc.identifier.uri10.5799/jcei/8294
dc.identifier.urihttp://hdl.handle.net/20.500.12627/1091
dc.description.abstractis an emerging pathogen in cystic fibrosis (CF) disease, although relatively limited is known about its clinical impact and optimal management. Pharmacodynamics such as post-antibiotic effect (PAE) are increasingly being applied to the design of antibiotic dosing regimens. In the present study, meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were tested for their PAE.Materials and Methods: The in vitro activities of meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were determined by the microbroth dilution technique. To determine the PAEs, A. xylosoxidans strains in the logarithmic phase of growth were exposed for 1 h to antibiotics. Recovery periods of test cultures were evaluated using viable counting after centrifugation.Results: The mean values of in vitro PAEs at 1xMIC and 4xMIC concentrations were 3.21 ± 0.66 and 3.58 ± 0.68 hours for colistin, 1.54 ± 0.46 and 2.27 ± 0.41 hours for levofloxacin, 2.34 ± 0.48 and 3.47 ± 0.64 hours for tobramycin, 1.72 ± 0.47 and 2.24 ± 0.41 hours for tigecycline 1.91 ± 0.14 and 2.13 ± 0.13 hours for chloramphenicol, respectively. The carbapenem antibiotics exhibited weak PAEs, as expected.Conclusions: This study’s findings could have important implications for the timing of doses during antimicrobial therapy with tested antibiotics.
dc.language.isoeng
dc.subjectClinical Medicine (Med)
dc.titlePost-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis
dc.typearticle
dc.contributor.departmentEczacılık Fakültesi,Temel Eczacılık,Farmasötik Mikrobiyoloji
dc.contributor.authorID0000-0001-8909-8398
dc.identifier.volume11
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.endpage5


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