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dc.contributor.authorCirit, Umut
dc.contributor.authorPabuccuoglu, Serhat
dc.contributor.authorBacınoğlu, Süleyman
dc.contributor.authorGok, Mehmet Koray
dc.contributor.authorOzsoy, Yildiz
dc.contributor.authorOzgumus, Saadet
dc.contributor.authorDemir, Kamber
dc.date.accessioned2020-09-29T11:06:51Z
dc.date.available2020-09-29T11:06:51Z
dc.date.issuedCevher, Erdal
dc.identifier.citation2016
dc.identifier.issnGok M. K. , Ozgumus S., Demir K., Cirit U., Pabuccuoglu S., Cevher E., Ozsoy Y., Bacınoğlu S., "Development Of Starch Based Mucoadhesive Vaginal Drug Delivery Systems For Application İn Veterinary Medicine", Carbohydrate Polymers, Vol.136, Pp.63-70, 2016
dc.identifier.uri0144-8617
dc.identifier.urihttp://hdl.handle.net/20.500.12627/1094
dc.description.abstract10.1016/j.carbpol.2015.08.079
dc.description.sponsorshipThe aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.
dc.publisherarticle
dc.subjecteng
dc.titleChemıstry, Applıed
dc.typeDevelopment of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine
dc.identifier.volumeEczacılık Fakültesi,Eczacılık Teknolojisi Bölümü
dc.identifier.issue136
dc.identifier.endpage63


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