Show simple item record

dc.contributor.authorMat, A.
dc.contributor.authorUydes-Dogan, Birsel Sönmez
dc.contributor.authorSezgi, B.
dc.contributor.authorTakir, S.
dc.contributor.authorAltun, I. H.
dc.contributor.authorSuzgec-Selcuk, Sevda
dc.date.accessioned2021-03-02T22:39:56Z
dc.date.available2021-03-02T22:39:56Z
dc.date.issued2015
dc.identifier.citationTakir S., Altun I. H. , Sezgi B., Suzgec-Selcuk S., Mat A., Uydes-Dogan B. S. , "Vasorelaxant and blood pressure lowering effects of alchemilla vulgaris: A comparative study of methanol and aqueous extracts", Pharmacognosy Magazine, cilt.11, sa.41, ss.163-169, 2015
dc.identifier.issn0973-1296
dc.identifier.othervv_1032021
dc.identifier.otherav_0dfcc17e-ca87-41f3-b1d7-c9241c3c8ef2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14991
dc.identifier.urihttps://doi.org/10.4103/0973-1296.149733
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84922167777&origin=inward
dc.description.abstractBackground: In the last decade, a growing interest particularly in determining the cardiovascular effects of herbal extracts took place among researchers. Objective: Herein, we aimed to investigate the microvascular and blood pressure lowering effects of two differently processed extracts of the same herb, Alchemilla vulgaris (Rosaceaea), which was revealed to contain high levels of vasoactive compounds. Materials and Methods: For the purpose, endothelium intact rat mesenteric arteries were mounted in a myograph system and contracted with prostaglandin F2α (PGF2α: 3 × 10-5 M) or potassium chloride (K+ : 40 mM). Then, aqueous and methanol extracts were added at 0.01-10 mg/ml concentrations in a cumulative manner. Results: Both extracts produced relaxations in PGF2α (3 × 10-5 M) precontracted arteries which were insensitive to the inhibitors of endothelium derived vasoactive substances namely, LG -nitro-L-arginine (10-4 M), ODQ (10-5 M) and indomethacin (10-5 M) or removal of endothelium. Opposite vascular effects were observed when extracts were applied in K+ precontracted arteries. In addition, oral administration of the methanol extract of Alchemilla vulgaris, but not the aqueous extract, reduced blood pressure significantly in L-NAME hypertensive rats. Conclusion: Our results demonstrated that the methanol extract of Alchemilla vulgaris has more prominent and favourable vascular effects in normal and experimental hypertensive conditions reinforcing its traditional use in cardiovascular disorders, in particular hypertension. These results most likely give rise to further studies to reveal its mechanism of action and clinical value of this herb.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleVasorelaxant and blood pressure lowering effects of alchemilla vulgaris: A comparative study of methanol and aqueous extracts
dc.typeMakale
dc.relation.journalPharmacognosy Magazine
dc.contributor.departmentMarmara Üniversitesi , ,
dc.identifier.volume11
dc.identifier.issue41
dc.identifier.startpage163
dc.identifier.endpage169
dc.contributor.firstauthorID49332


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record