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dc.contributor.authorBAYRAK, Bertan Boran
dc.contributor.authorMutlu, Ozgur
dc.contributor.authorYANARDAĞ, Refiye
dc.contributor.authorAkev, Nuriye
dc.contributor.authorSAÇAN, Özlem
dc.contributor.authorTÜRKYILMAZ, İsmet Burcu
dc.date.accessioned2021-03-02T22:43:59Z
dc.date.available2021-03-02T22:43:59Z
dc.identifier.citationSAÇAN Ö., TÜRKYILMAZ İ. B. , BAYRAK B. B. , Mutlu O., Akev N., YANARDAĞ R., "Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2020
dc.identifier.issn1095-6670
dc.identifier.othervv_1032021
dc.identifier.otherav_0e5e0ca7-50f9-46cc-b892-1edcda5b01ef
dc.identifier.urihttp://hdl.handle.net/20.500.12627/15238
dc.identifier.urihttps://doi.org/10.1002/jbt.22617
dc.description.abstractDiabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas in diabetic complications. In this study, we aimed to investigate the protective role of Zn in liver damage in streptozotocin (STZ)-induced diabetes mellitus. There are four experimental groups of female Swiss albino rats: group I: control; group II: control + ZnSO4; group III: STZ-induced diabetic animals and group IV: STZ-diabetic + ZnSO4. To induce diabetes, STZ was injected intraperitoneally (65 mg/kg). ZnSO4(100 mg/kg) was given daily to groups II and IV by gavage for 60 days. At the end of the experiment, rats were killed under anaesthesia and liver tissues were collected. In the diabetic group, hexose, hexosamine, fucose, sialic acid levels, arginase, adenosine deaminase, tissue factor activities and protein carbonyl levels increased, whereas catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase and Na+/K+-ATPase activities decreased. The administration of Zn to the diabetic group reversed all the negative effects/activities. According to these results, we can suggest that Zn has a protective role against STZ-induced diabetic liver damage.
dc.language.isoeng
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectToxicology
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.titleProtective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters
dc.typeMakale
dc.relation.journalJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Mühendislik Fakültesi , Kimya Bölümü
dc.contributor.firstauthorID2284984


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