dc.contributor.author | Kucukyalcin, Volkan | |
dc.contributor.author | Yilmaz, Murat | |
dc.contributor.author | Guzel, Savas | |
dc.contributor.author | Celik, Cem | |
dc.contributor.author | Bastu, Ercan | |
dc.contributor.author | Abali, Remzi | |
dc.date.accessioned | 2021-03-02T22:44:37Z | |
dc.date.available | 2021-03-02T22:44:37Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Celik C., Abali R., Guzel S., Bastu E., Kucukyalcin V., Yilmaz M., "Elevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome", CLINICAL ENDOCRINOLOGY, cilt.77, sa.6, ss.893-897, 2012 | |
dc.identifier.issn | 0300-0664 | |
dc.identifier.other | av_0e5ffb0b-5207-46ad-bac4-3b668da351d8 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/15241 | |
dc.identifier.uri | https://doi.org/10.1111/j.1365-2265.2012.04437.x | |
dc.description.abstract | Objective This study investigates human cartilage glycoprotein-39 (YKL-40) levels in patients with polycystic ovary syndrome (PCOS) and controls, and tests their relationship with metabolic and hormonal parameters. Design Clinical study carried out in a university hospital in Tekirdag, Turkey. Patients Eighty-five women with PCOS and normal glucose tolerance (NGT) and twenty-five women with PCOS and abnormal glucose tolerance (AGT), diagnosed according to Rotterdam criteria, and fifty-nine healthy women. Measurements YKL-40 levels, fasting hormone levels and metabolic parameters were investigated in all subjects. Results We showed increased YKL-40 levels in women with PCOS compared to controls. (152.57 +/- 3.96 mu g/l vs 98.16 +/- 1.6 mu g/l, P < 0.000). YKL significantly correlated with BMI (r = 0.344; P < 0.000), 2-h glucose (r = 0.193; P = 0.012), HOMA-IR (r = 0.268; P < 0.000) and fasting insulin (r = 0.310; P < 0.000), but not with waist/hip ratio (r = 0.016; P = 0.832) and fasting glucose (r = 0.108; P = 0.832). When ROC curve analysis was used to analyse the suitability of YKL-40 to identify glucose intolerance in women with PCOS, area under curve for YKL-40 was found to be significant (AGT-PCOS: AUC 0.632, P = 0.046). Conclusion Plasma YKL-40 levels increased in patients with PCOS compared to healthy subjects. Moreover, there was a significant difference in YKL-40 levels between AGT-PCOS and NGT-PCOS subjects. Subsequently, we also found that YKL-40 levels above the cut-off point may help the clinician to predict abnormal glucose tolerance in patients with PCOS. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.title | Elevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome | |
dc.type | Makale | |
dc.relation.journal | CLINICAL ENDOCRINOLOGY | |
dc.contributor.department | Tekirdağ Namık Kemal Üniversitesi , , | |
dc.identifier.volume | 77 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 893 | |
dc.identifier.endpage | 897 | |
dc.contributor.firstauthorID | 207042 | |