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dc.contributor.authorMills, Ken
dc.contributor.authorSayitoglu, Müge
dc.contributor.authorO'hagan, Kathleen
dc.contributor.authorOzbek, Ugur
dc.contributor.authorKeeshan, Karen
dc.contributor.authorHannon, Maura M.
dc.contributor.authorLohan, Fiona
dc.contributor.authorErbilgin, Yucel
dc.date.accessioned2021-03-02T22:45:08Z
dc.date.available2021-03-02T22:45:08Z
dc.identifier.citationHannon M. M. , Lohan F., Erbilgin Y., Sayitoglu M., O'hagan K., Mills K., Ozbek U., Keeshan K., "Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL", BRITISH JOURNAL OF HAEMATOLOGY, cilt.158, ss.626-634, 2012
dc.identifier.issn0007-1048
dc.identifier.othervv_1032021
dc.identifier.otherav_0e6e8970-20d7-457b-830d-928f26a51cd4
dc.identifier.urihttp://hdl.handle.net/20.500.12627/15280
dc.identifier.urihttps://doi.org/10.1111/j.1365-2141.2012.09222.x
dc.description.abstractTRIB2 is a potent oncogene, elevated in a subset of human acute myeloid leukaemias (AML) with a mixed myeloid/lymphoid phenotype and NOTCH1 mutations. Although rare in AML, activating NOTCH1 mutations occur in 50% of all T cell acute lymphoblastic leukaemias (T-ALL). TRIB2 is a NOTCH1 target gene that functions in the degradation of key proteins and modulation of MAPK signalling pathways, implicated in haematopoietic cell survival and proliferation. This study showed that TRIB2 expression level is highest in the lymphoid compartment of normal haematopoietic cells, specifically in T cells. Analysis of TRIB2 expression across 16 different subtypes of human leukaemia demonstrated that TRIB2 expression was higher in ALL phenotypes versus all other phenotypes including AML, chronic lymphocytic leukaemia (CLL), myelodysplastic syndrome (MDS) and chronic myeloid leukaemia (CML). A T cell profile was distinguished by high TRIB2 expression in normal and malignant haematopoiesis. High TRIB2 expression was seen in T-ALL with normal karyotype and correlated with NOTCH signalling pathways. High TRIB2 expression correlated with NOTCH1/FBXW7 mutations in a paediatric T-ALL cohort, strongly linking NOTCH1 activation and high TRIB2 expression in paediatric T-ALL. The relationship between TRIB2 and T cell signalling pathways uniquely identifies leukaemia subtypes and will be useful in the advancement of our understanding of T cell and ALL biology.
dc.language.isoeng
dc.subjectHematoloji
dc.subjectSağlık Bilimleri
dc.subjectİç Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectHEMATOLOJİ
dc.titleElevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL
dc.typeMakale
dc.relation.journalBRITISH JOURNAL OF HAEMATOLOGY
dc.contributor.departmentNational University Of Ireland, University College Cork , ,
dc.identifier.volume158
dc.identifier.startpage626
dc.identifier.endpage634
dc.contributor.firstauthorID1040897


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