dc.contributor.author | Utku, Elif Gozde | |
dc.contributor.author | Uner, Melike | |
dc.contributor.author | Karaman, Ecem Fatma | |
dc.contributor.author | Yener, Gulgun | |
dc.contributor.author | ERGÜVEN, MİNE | |
dc.date.accessioned | 2021-03-02T22:55:19Z | |
dc.date.available | 2021-03-02T22:55:19Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Uner M., Yener G., ERGÜVEN M., Karaman E. F. , Utku E. G. , "Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Celecoxib for Topical Application - Preparation, Characterization and Drug Penetration Through Rat Skin", CURRENT NANOSCIENCE, cilt.10, sa.4, ss.532-542, 2014 | |
dc.identifier.issn | 1573-4137 | |
dc.identifier.other | av_0f7c504c-2418-48c7-b827-1a781560a1aa | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/15947 | |
dc.identifier.uri | https://doi.org/10.2174/1573413710666140218231307 | |
dc.description.abstract | Lipid nanoparticles have been paid growing interest for topical application of non-steroidal anti-inflammatory drugs to increase skin penetration and to reduce side effects. Solid lipid nanoparticles and nanostructured lipid carriers of celecoxib were prepared by high-pressure homogenization technique. Transmission electron microscopy, fourier transform infrared spectroscopy, differential scanning calorimetry, photon correlation spectroscopy and laser diffraction were used for characterization of nanoparticles. Their physical stability was investigated for 6 months of storage at the room temperature, 4 degrees C and 40 degrees C. Nanoemulsions were also prepared at the same conditions for comparison with the aim of pyhsico-chemical characterization of nanoparticles. Spherical nanoparticles with high drug payload were obtained below 250 nm when similar particle sizes were observed for 3 months of storage at all temperatures. Low microparticle content was detected in formulations after 6 months when d(0.5) values were below 270 nm at room temperature and 4 degrees C. 40 degrees C was not detected as a suitable storage condition for formulations. Nanoparticles were observed to provide controlled drug release. Their release profiles fitted Korsmeyer-Peppas model indicating Fickian diffusion release (case I diffusional) as the dominant mechanism. In ex-vivo skin penetration experiments through abdominal rat skins, solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion significantly increased drug penetration rate 1.4-2.2 times higher compared to a traditional gel formulation containing celecoxib (p0.05). Nanoemulsion displayed the highest drug penetration rate among nano-formulations. Lipid nanoparticles and nanoemulsion were found as good canditates in order to transport celecoxib through deeper skin layers increasing drug penetration. | |
dc.language.iso | eng | |
dc.subject | Mühendislik, Bilişim ve Teknoloji (ENG) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyoteknoloji | |
dc.subject | Yoğun Madde 1:Yapısal, Mekanik ve Termal Özellikler | |
dc.subject | Yüzeyler ve arayüzeyler; İnce filmler ve nanosistemler | |
dc.subject | Temel Bilimler | |
dc.subject | Mühendislik ve Teknoloji | |
dc.subject | MALZEME BİLİMİ, MULTIDISCIPLINARY | |
dc.subject | Malzeme Bilimi | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Fizik | |
dc.subject | NANOBİLİM VE NANOTEKNOLOJİ | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Mikrobiyoloji | |
dc.subject | BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ | |
dc.title | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Celecoxib for Topical Application - Preparation, Characterization and Drug Penetration Through Rat Skin | |
dc.type | Makale | |
dc.relation.journal | CURRENT NANOSCIENCE | |
dc.contributor.department | İstanbul Aydın Üniversitesi , Sağlık Hizmetleri Meslek Yüksekokulu , Patoloji Laboratuvar Teknikleri Pr. | |
dc.identifier.volume | 10 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 532 | |
dc.identifier.endpage | 542 | |
dc.contributor.firstauthorID | 212303 | |