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dc.contributor.authorSohail, Muhammad Imran
dc.contributor.authorAdylova, Aima
dc.contributor.authorKonysbayevna, Konysbayeva Kenzhekul
dc.contributor.authorBuha, Aleksandra
dc.contributor.authorAras, Aliye
dc.contributor.authorQureshi, Muhammad Zahid
dc.contributor.authorAttar, Rukset
dc.contributor.authorJaved, Anam
dc.contributor.authorSabitaliyevich, Uteuliyev Yerzhan
dc.date.accessioned2021-03-02T22:57:39Z
dc.date.available2021-03-02T22:57:39Z
dc.date.issued2019
dc.identifier.citationQureshi M. Z. , Attar R., Javed A., Sabitaliyevich U. Y. , Adylova A., Konysbayevna K. K. , Buha A., Sohail M. I. , Aras A., "Focusing on the brighter side of Sevoflurane: Realizing true potential of an anesthetic agent as a regulator of cell signaling pathways and microRNAs in different cancers", CELLULAR AND MOLECULAR BIOLOGY, cilt.65, sa.8, ss.7-10, 2019
dc.identifier.issn0145-5680
dc.identifier.othervv_1032021
dc.identifier.otherav_0fa47c21-d22c-4316-bfc8-07f43d182dc9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16054
dc.identifier.urihttps://doi.org/10.14715/cmb/2019.65.8.2
dc.description.abstractReconceptualization of different anesthetics as anticancer agents has opened new horizons for a better and sharper analysis of true potential of Sevoflurane as a promising and frontline candidate in the pipeline of anticancer agents. Sevoflurane mediated regulation of cell signaling pathways and non-coding RNAs has leveraged our understanding to another level. There have been remarkable advancements in unraveling mechanistic insights related to the ability of sevoflurane to modulate microRNAs in different cancers. Astonishingly, sevoflurane mediated regulation of miRNAs and long non-coding RNAs have been more comprehensively addressed in ischemia-reperfusion injuries. However, researchers yet have to gather missing pieces of premium research-work to uncover mechanistic regulation of long non-coding RNAs by sevoflurane in various cancers. Sevoflurane modulated control of miRNAs have been reported in glioma, colorectal cancer, breast cancer and hepatocellular carcinoma. In this review we have attempted to summarize most recent cutting edge and high-impact experimental researches which have elucidated myriad of underlying mechanisms modulated by sevoflurane to inhibit cancer development and progression. Despite some of the amazing pharmacological properties of sevoflurane, it has been shown to possess darker side because of its involvement in positive regulation of metastasis. In accordance with this notion we have also summarized how sevoflurane enhanced migratory potential of different cancer cells in a separate section. Therefore, these aspects have to be tested in better designed experimental models to identify most relevant types of cancers which can be therapeutically targeted by sevoflurane.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.titleFocusing on the brighter side of Sevoflurane: Realizing true potential of an anesthetic agent as a regulator of cell signaling pathways and microRNAs in different cancers
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY
dc.contributor.departmentQassim University , ,
dc.identifier.volume65
dc.identifier.issue8
dc.identifier.startpage7
dc.identifier.endpage10
dc.contributor.firstauthorID1043853


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