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dc.contributor.authorGorgun, O
dc.contributor.authorAYAN, İnci
dc.contributor.authorKebudi, Rejin
dc.date.accessioned2021-03-02T22:57:54Z
dc.date.available2021-03-02T22:57:54Z
dc.date.issued2004
dc.identifier.citationKebudi R., Gorgun O., AYAN İ., "Oral etoposide for recurrent/progressive sarcomas of childhood", PEDIATRIC BLOOD & CANCER, cilt.42, sa.4, ss.320-324, 2004
dc.identifier.issn1545-5009
dc.identifier.othervv_1032021
dc.identifier.otherav_0fabffa4-403d-45a3-93a7-77e865b2dd0f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16073
dc.identifier.urihttps://doi.org/10.1002/pbc.10393
dc.description.abstractBackground. Etoposide (VP-16) is a topoisomerase 11 inhibitor that is effective in a broad spectrum of pediatric and adult malignancies. Chronic, low-dose, oral VP-16 has also been shown to be active in some recurrent malignancies mostly in adults. The aim of this prospective, single institution study is to assess the efficacy and toxicity of oral VP-16 in children with progressive or recurrent (P/R) sarcomas. Procedure. Twenty-one children (10 girls and 11 boys) with R/P sarcomas and a median age of 11 years (range 3-16 years) were enrolled in this study. The diagnosis was Ewing sarcoma family tumor (ESFT) in seven, osteosarcoma in eight, rhabdomyosarcoma in four, clear cell sarcoma of soft tissue in one, fibrosarcoma in one patient. Oral VP-16 was administered at a dose of 50 mg/m(2)/daily for 20 days. The next course was initiated after a 10 day rest. Response to oral VP-16 was assessed after two courses. Results. There was an objective response (one complete response [CR], two partial responses [PR]) in three patients (14%) by two courses of oral VP-16 alone. One of these patients with PR achieved CR by the use of radiotherapy (RT) and further oral VP-16. Two more patients (9.5%) achieved CR by RT and oral VP-16. Eight (38%) patients had disease stabilization for 2-15 months. Two patients (9.5%) are long-term survivors. They are alive with no evidence of disease (NED) 79 and 94 months from time of relapse/progressive disease (PD). A patient developed acute myeloid leukemia and died. There was no major acute toxicity related to oral VP-16 in a total of 126 courses. Conclusions. Oral VP-16 therapy is simple, relatively nontoxic, and does not necessitate hospitalization. The cure rate is small. Given the risk of second malignancy, especially in children with previous exposure to topoisomerase 11 inhibitors and alkylating agents, this regimen may be used as a palliative treatment or in patients with poor prognosis. (C) 2003 Wiley-Liss, Inc.
dc.language.isoeng
dc.subjectHematoloji
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectPEDİATRİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectHEMATOLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleOral etoposide for recurrent/progressive sarcomas of childhood
dc.typeMakale
dc.relation.journalPEDIATRIC BLOOD & CANCER
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume42
dc.identifier.issue4
dc.identifier.startpage320
dc.identifier.endpage324
dc.contributor.firstauthorID16228


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