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dc.contributor.authorYilmaz, Vuslat
dc.contributor.authorAysal, Fikret
dc.contributor.authorDeymeer, Feza
dc.contributor.authorGulsen-Parman, Yesim
dc.contributor.authorSaruhan-Direskeneli, Güher
dc.contributor.authorOflazer, Piraye
dc.contributor.authorAlahgholi-Hajibehzad, Mahdi
dc.date.accessioned2021-03-02T23:01:37Z
dc.date.available2021-03-02T23:01:37Z
dc.date.issued2013
dc.identifier.citationAlahgholi-Hajibehzad M., Yilmaz V., Gulsen-Parman Y., Aysal F., Oflazer P., Deymeer F., Saruhan-Direskeneli G., "Association of HLA-DRB1*14, -DRB1*16 and -DQB1*05 with MuSK-myasthenia gravis in patients from Turkey", Human Immunology, cilt.74, sa.12, ss.1633-1635, 2013
dc.identifier.issn0198-8859
dc.identifier.otherav_10031cd4-09f3-4740-b2d4-bbeba7c2ae59
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16288
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84888201790&origin=inward
dc.identifier.urihttps://doi.org/10.1016/j.humimm.2013.08.271
dc.description.abstractSusceptibility to myasthenia gravis (MG) has been demonstrated with several HLA in different disease subgroups. HLA-DR14, -DR16 and -DQ5 were reported as predisposing factors in muscle-specific kinase antibody positive MG (MuSK-MG). These markers were evaluated in MG subgroups from Turkey. Among 164 generalized MG patients, 116 had antibodies against anti-acetylcholine receptor (AChR-MG) and 48 had MuSK-MG. Only HLA-DRB1 and DQB1 allele groups reported to be associated with MuSK-MG were compared with 250 healthy controls (HC). Highly significant associations of both DRB1*16 and DRB1*14 were found with MuSK-MG compared to HC (p=1.9×10-5, OR: 4.95 and p=0.0028, OR: 3.1). On the contrary, HLA-DRB1*03 was less frequent in MuSK-MG (p=0.006, OR: 0.09). DQB1*05 was also associated with MuSK-MG (p=2.5×10-6 OR: 4.8). This study provides a replication of the highly significant associations of both HLA-DRB1*16,-DRB1*14 and -DQB1*05 with MuSK-MG. Moreover, HLA-DRB1*03 appears to have a distinguishing role for this disease subgroup compared to early-onset and AChR-MG. © 2013 American Society for Histocompatibility and Immunogenetics.
dc.language.isoeng
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleAssociation of HLA-DRB1*14, -DRB1*16 and -DQB1*05 with MuSK-myasthenia gravis in patients from Turkey
dc.typeMakale
dc.relation.journalHuman Immunology
dc.contributor.departmentIstanbul Bakirkoy Mental Health & Neurology Training & Research Hospital , ,
dc.identifier.volume74
dc.identifier.issue12
dc.identifier.startpage1633
dc.identifier.endpage1635
dc.contributor.firstauthorID24281


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