dc.contributor.author | Senyigit, A. | |
dc.contributor.author | Konukoglu, D. | |
dc.contributor.author | Gultepe, I | |
dc.contributor.author | Uzun, H. | |
dc.date.accessioned | 2021-03-02T23:02:13Z | |
dc.date.available | 2021-03-02T23:02:13Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Senyigit A., Uzun H., Gultepe I., Konukoglu D., "The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases", BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.120, sa.3, ss.188-194, 2019 | |
dc.identifier.issn | 0006-9248 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_101708c6-1e8e-4d01-9196-a0613a5abba1 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/16333 | |
dc.identifier.uri | https://doi.org/10.4149/bll_2019_032 | |
dc.description.abstract | We investigated the association between carotid intima-media thickness (CIMT) with clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) levels, and dipeptidyl peptidase-4 (DPP-4) in type 2 diabetes mellitus (T2DM) individuals with or without coronary artery disease (CAD). This study consisted of four groups: control group (mean ages: 50.3 +/- 10.7 years; 20 females and 15 males), diabetic group (DM; mean ages: 53.9 +/- 11.1; 14 females and 23 males), CAD group (mean ages: 60.1 +/- 43.5; 17 females and 17 males) and CAD+ DM group (mean ages: 62.6 +/- 11.8 years; 18 females and 18 males). CIMT levels in both CAD and CAD+ DM groups are higher than those in controls. CIMT levels in CAD+ DM group are also signifi cantly higher than those in DM group. Left external carotid artery (ECA) was found different from controls only in DM group. The levels of SFRP-4 in control group were signifi cantly lower than those in DM, CAD and CAD+ DM groups. Serum GLP-1 total levels were found to be signifi cantly low in CAD+ DM group when compared to control group. DPP-4 and SFRP-4 levels may be a predictive marker for atherosclerosis in diabetes while particularly in diabetes, they correlate well with HOMA-IR. CIMT has the potential to be a clinically useful predictor of vascular risk in diabetic patients with CAD (Tab. 3, Fig. 2, Ref. 39). | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.title | The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases | |
dc.type | Makale | |
dc.relation.journal | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | |
dc.contributor.department | Medipol Hospital , , | |
dc.identifier.volume | 120 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 188 | |
dc.identifier.endpage | 194 | |
dc.contributor.firstauthorID | 260901 | |