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dc.contributor.authorCelebi, Benek
dc.contributor.authorUner, Melike
dc.date.accessioned2021-03-02T23:06:04Z
dc.date.available2021-03-02T23:06:04Z
dc.date.issued2012
dc.identifier.citationUner M., Celebi B., "Design of Hydralazine Hydrochloride Matrix Tablets Based on Various Polymers and Lipids", INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, cilt.46, sa.1, ss.75-87, 2012
dc.identifier.issn0019-5464
dc.identifier.othervv_1032021
dc.identifier.otherav_107a6912-65d8-43c8-b1de-6b8cbc9ce173
dc.identifier.urihttp://hdl.handle.net/20.500.12627/16578
dc.description.abstractThe purpose of this study was to design matrix tablets of hydralazine hydrochloride to overcome its side effects and to increase its bioavailability. Hydroxypropyl methylcellulose, carbomer, glyceryl dibehenate and cetyl alcohol were used in matrix tablets at various concentrations for sustained drug delivery. Compression and flow properties of powder mixtures were tested before tablets were compressed by direct compression method. Weight variation, diameter and thickness, hardness, tensile strength, friability % and disintegration time of tablets were tested for their physical characterization. Drug:excipient compatibility in tablets was investigated by Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. Determination method of drug in dissolution mediums was validated through following performance criteria: linearity, intra- and inter-day precision, accuracy, specifity and recovery. All formulations met compendial requirements and any chemical interaction between drug and tablet excipients was not detected. It was observed that waxy tablets released drug faster than polymer based tablets. The slowest drug release rate was obtained with carbomer matrix tablets followed by hydroxypropyl methylcellulose, glyceryl dibehenate and cetyl alcohol. Drug release met Higuchi kinetic model in general. While the mechanism of drug release from polymer based tablets was non-Fickian, waxy tablets generally displayed diffusionally controlled drug release.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectEğitim
dc.subjectBilgisayar ve Öğretim Teknolojisi Eğitimi
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectEĞİTİM VE EĞİTİM ARAŞTIRMASI
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectSosyal Bilimler (SOC)
dc.subjectSosyal Bilimler Genel
dc.subjectEĞİTİM, BİLİMSEL DİSİPLİNLER
dc.titleDesign of Hydralazine Hydrochloride Matrix Tablets Based on Various Polymers and Lipids
dc.typeMakale
dc.relation.journalINDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume46
dc.identifier.issue1
dc.identifier.startpage75
dc.identifier.endpage87
dc.contributor.firstauthorID54180


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