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dc.contributor.authorBayrak, Bertan Boran
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorKayalar, Ozgecan
dc.contributor.authorÖztay, Füsün
dc.date.accessioned2021-03-12T14:04:00Z
dc.date.available2021-03-12T14:04:00Z
dc.date.issued2013
dc.identifier.citationÖztay F., Bayrak B. B. , Kayalar O., Yanardağ R., "EFFECTS OF ALL-TRANS RETINOIC ACID ON REDUCING HYPEROXIA-INDUCED OXIDATIVE STRESS IN MICE BRAIN.", Nobel Medicus, cilt.9, sa.3, ss.22-26, 2013
dc.identifier.issn1305-2381
dc.identifier.othervv_1032021
dc.identifier.otherav_7e15df91-d053-4b05-ae93-16e06cef50fc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/167773
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/7e15df91-d053-4b05-ae93-16e06cef50fc/file
dc.description.abstractABSTRACTObjective: Brain is a very sensitive organ to oxidative stress due to its large amount of polyunsaturated fatty acid content and low antioxidant activity. In this study, effect of exogenous all-trans-retinoic acid (RA) on brain antioxidant activity was investigated in mice under hyperoxia-induced oxidative stress.Material and Method: Adult C57BL/6J mice were divided into 4 groups. Two groups were given daily either peanut oil/dimethylesulfoxide (PoDMSO) mixture or 50 mg/kg RA dissolved in PoDMSO (RA-PoDMSO). The remaining two groups were treated with PoDMSO or RAPoDMSO as described above, following hyperoxia (100% oxygen) for 72 h. The treatments were given daily 50 µl intraperitoneal injections for 12 days, with a 2 day interruption on days 6 and 7. Lipid peroxidation (LPO) and glutathione (GSH) levels as well as activities of several antioxidant enzymes were assayed in brain tissue to evaluate oxidative stress, biochemically.Results: Elevated LPO levels, increased catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase activities, and decreased GSH levels were observed in hyperoxic mice. RA administration to hyperoxic mice improved these biochemical alterations in favour of reduced oxidative stress.Conclusion: Exogenous RA, a small lipophilic molecule, is effective in reducing oxidative stress in the brain which can receive only small lipophilic molecules due to the presence of the blood-brain barrier. Also, RA exhibits an antioxidant effect by inhibiting the GSH depletion and increased LPO levels in brain of hyperoxic mice, directly.
dc.language.isoeng
dc.subjectMultidisciplinary
dc.subjectTemel Bilimler
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.titleEFFECTS OF ALL-TRANS RETINOIC ACID ON REDUCING HYPEROXIA-INDUCED OXIDATIVE STRESS IN MICE BRAIN.
dc.typeMakale
dc.relation.journalNobel Medicus
dc.contributor.departmentİstanbul Üniversitesi , Fen Fakültesi , Biyoloji Bölümü
dc.identifier.volume9
dc.identifier.issue3
dc.identifier.startpage22
dc.identifier.endpage26
dc.contributor.firstauthorID2529563


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