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dc.contributor.authorBarkhof, Frederik
dc.contributor.authorvan der Flier, Wiesje M.
dc.contributor.authorErkoyun, Hulya Ulugut
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorNijmeijer, Bas
dc.contributor.authorvan Spaendonk, Rosalina
dc.contributor.authorNelissen, Anne
dc.contributor.authorScarioni, Marta
dc.contributor.authorDijkstra, Anke
dc.contributor.authorSamancı, Bedia
dc.contributor.authorGÜRVİT, İbrahim Hakan
dc.contributor.authorYıldırım, Zerrin
dc.contributor.authorTepgeç, Fatih
dc.contributor.authorBilgic, Basar
dc.contributor.authorRozemuller, Annemieke
dc.contributor.authorPijnenburg, Yolande
dc.contributor.authorCohn-Hokke, Petra
dc.contributor.authorScheltens, Philip
dc.date.accessioned2021-03-02T15:46:33Z
dc.date.available2021-03-02T15:46:33Z
dc.date.issued2021
dc.identifier.citationErkoyun H. U. , van der Lee S. J. , Nijmeijer B., van Spaendonk R., Nelissen A., Scarioni M., Dijkstra A., Samancı B., GÜRVİT İ. H. , Yıldırım Z., et al., "The right temporal variant of frontotemporal dementia is not genetically sporadic: A case series", Journal of Alzheimer's Disease, cilt.79, sa.3, ss.1195-1201, 2021
dc.identifier.issn1387-2877
dc.identifier.othervv_1032021
dc.identifier.otherav_aba2e766-adf7-4819-ab2d-54b9045101aa
dc.identifier.urihttp://hdl.handle.net/20.500.12627/1727
dc.identifier.urihttps://doi.org/10.3233/jad-201191
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/aba2e766-adf7-4819-ab2d-54b9045101aa/file
dc.description.abstract© 2021 - IOS Press. All rights reserved.Background: Right temporal variant frontotemporal dementia (rtvFTD) has been generally considered as a right sided variant of semantic variant primary progressive aphasia (svPPA), which is a genetically sporadic disorder. Recently, we have shown that rtvFTD has a unique clinical syndrome compared to svPPA and behavioral variant frontotemporal dementia. Objective: We challenge the assumption that rtvFTD is a sporadic, non-familial variant of FTD by identifying potential autosomal dominant inheritance and related genes in rtvFTD. Methods: We collected all subjects with a diagnosis of FTD or primary progressive aphasia who had undergone genetic screening (n = 284) and subsequently who had a genetic variant (n = 48) with a diagnosis of rtvFTD (n = 6) in 2 specialized memory clinics. Results: Genetic variants in FTD related genes were found in 33% of genetically screened rtvFTD cases; including MAPT (n = 4), GRN (n = 1), and TARDBP (n = 1) genes, whereas only one svPPA case had a genetic variant in our combined cohorts. Additionally, 4 out of 6 rtvFTD subjects had a strong family history for dementia. Conclusion: Our results demonstrate that rtvFTD, unlike svPPA, is not a pure sporadic, but a heterogeneous potential genetic variant of FTD, and screening for genetic causes for FTD should be performed in patients with rtvFTD.
dc.language.isoeng
dc.subjectClinical Psychology
dc.subjectKlinik Psikolojisi
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectGeneral Neuroscience
dc.subjectLife Sciences
dc.subjectSocial Sciences & Humanities
dc.subjectGeriatrics and Gerontology
dc.subjectHealth Sciences
dc.subjectPsychiatry and Mental Health
dc.subjectKlinik Tıp (MED)
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectPsikiyatri
dc.subjectPsikoloji
dc.subjectSinirbilim ve Davranış
dc.subjectGERİATRİK VE GERONTOLOJİ
dc.subjectPSİKOLOJİ, KLİNİK
dc.subjectNEUROSCIENCES
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGeriatri
dc.subjectSosyal ve Beşeri Bilimler
dc.titleThe right temporal variant of frontotemporal dementia is not genetically sporadic: A case series
dc.typeMakale
dc.relation.journalJournal of Alzheimer's Disease
dc.contributor.departmentVrije Universiteit Amsterdam , ,
dc.identifier.volume79
dc.identifier.issue3
dc.identifier.startpage1195
dc.identifier.endpage1201
dc.contributor.firstauthorID2521883


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