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dc.contributor.authorIpek, Yonal
dc.contributor.authorHulya, Dogru
dc.contributor.authorMelih, Aktan
dc.date.accessioned2021-12-10T11:59:33Z
dc.date.available2021-12-10T11:59:33Z
dc.identifier.citationIpek Y., Hulya D., Melih A., "Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia", CASE REPORTS IN MEDICINE, cilt.2012, 2012
dc.identifier.othervv_1032021
dc.identifier.otherav_a214ce2e-452e-4f63-8cdb-08f46e5b1bc4
dc.identifier.urihttp://hdl.handle.net/20.500.12627/173043
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/a214ce2e-452e-4f63-8cdb-08f46e5b1bc4/file
dc.identifier.urihttps://doi.org/10.1155/2012/236174
dc.description.abstractAcute promyelocytic leukemia (APL) is a biologically and clinically separate type of acute myeloid leukemia characterized by a translocation involving the retinoic acid receptor-alpha (RARa) locus on chromosome 17, the great majority of which is t(15; 17)(q24.1; q21.1) (Collins (1998), Melnick and Licht (1999), and Grimwade (1999)). Retinoic acid is a critical ligand in the differentiation pathway of multiple tissues, mediated through binding to an RAR. All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al. (1993), Liu et al. (2000), and Cassinat et al. (2001)). ATRA-associated toxicity consisting of headache, fever, weakness, fatigue, dry skin, dermatitis, gastrointestinal disorders, and hypertriglyceridemia has been shown to be mild (Kurzrock et al. (1993)). Herein, we describe a patient with APL that developed an erythematous reaction of the whole body followed by desquamation and exfoliation during ATRA therapy.
dc.language.isoeng
dc.subjectInternal Medicine
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectFamily Practice
dc.subjectFundamentals and Skills
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectKlinik Tıp (MED)
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectHealth Sciences
dc.titleDisseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia
dc.typeMakale
dc.relation.journalCASE REPORTS IN MEDICINE
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume2012
dc.contributor.firstauthorID2736654


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