Processing of neural activity in the human subthalamus in Parkinson's disease: Movement-related and pharmacological modulation

Abstract

Electrodes for Deep Brain Stimulation offer the unique opportunity to record neural activity from the basal ganglia and to study their pathophysiology in living humans. Using time-frequency analysis techniques it is possible to evaluate the dependence of the spectral properties of human basal ganglia signals (1) on voluntary movement and (2) on drug administration. In this paper some of the results obtained by our group are reviewed and discussed.