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dc.contributor.authorDogan, Zeliha
dc.contributor.authorErgen, Arzu
dc.contributor.authorGheybi, Arezoo
dc.contributor.authorAkbas, Feray
dc.contributor.authorZeybek, Umit
dc.contributor.authorOguz, Osman
dc.date.accessioned2022-07-04T13:03:47Z
dc.date.available2022-07-04T13:03:47Z
dc.identifier.citationOguz O., Gheybi A., Dogan Z., Akbas F., Zeybek U., Ergen A., "Investigation of GHRL (RS4684677), FTO (RS8044769) and PGC1 Alpha (RS8192678) polymorphisms in type 2 diabetic Turkish population", TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2022
dc.identifier.issn0250-4685
dc.identifier.othervv_1032021
dc.identifier.otherav_382e2f15-d7b2-49e9-a4e8-41d2fc3aa515
dc.identifier.urihttp://hdl.handle.net/20.500.12627/182313
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/382e2f15-d7b2-49e9-a4e8-41d2fc3aa515/file
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0235
dc.description.abstractObjectives Diabetes is a chronic group of metabolic disorders those generally present with hyperglycemia hence insulin synthesis defects due to multifactorial causes in beta cells in the Langerhans islets of the pancreas. In the development of diabetes, genetic predisposition is as important as environmental factors. As a result of polymorphism studies in diabetic patients, many genes were associated with the development of diabetes. In our study, we aimed to represent the relationship between diabetes and certain variants of the Ghrelin (GHRL), Fat mass and obesity-associated protein (FTO) and Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1 alpha) genes which are generally associated with diabetes and obesity. Methods One-hundred type 2 diabetes mellitus (T2DM) patients and ninety-four healthy volunteers were enrolled in our study. GHRL (rs4684677), FTO (rs8044769) and PGC-1 alpha (rs8192678) gene polymorphism studies were performed by the Real-Time PCR method. Results The carriers of the TT genotype for the FTO (rs8044769) and the GG genotype for the PGC-1 alpha (rs8192678) variants were found more frequently in the patient group, while the GHRL (rs4684677) did not differ between the groups. For the PGC-1 alpha (rs8192678) variant in the patient group, glucose and BMI levels were observed significantly higher in carriers of the GA genotype than those with the GG genotype. There was no statistical difference in the distribution of GHRL (rs4684677) alleles among the groups. Conclusions We conclude that the FTO (rs8044769) and PGC-1 alpha (rs8192678) variants are associated with T2DM in the Turkish population. However, there is no association between GHRL (rs4684677) and T2DM.
dc.language.isoeng
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectLife Sciences
dc.subjectYaşam Bilimleri
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.titleInvestigation of GHRL (RS4684677), FTO (RS8044769) and PGC1 Alpha (RS8192678) polymorphisms in type 2 diabetic Turkish population
dc.typeMakale
dc.relation.journalTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
dc.contributor.departmentAmer Hosp , ,
dc.contributor.firstauthorID3432260


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