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dc.contributor.authorMills, Gary
dc.contributor.authorWolmann, Marcus
dc.contributor.authorMazzinari, Guido
dc.contributor.authorSerpa Neto, Ary
dc.contributor.authorHemmes, Sabrine
dc.contributor.authorHedenstierna, Goran
dc.contributor.authorJaber, Samir
dc.contributor.authorHiesmayr, Michael
dc.contributor.authorÇamcı, Ali Emre
dc.date.accessioned2022-07-04T13:05:59Z
dc.date.available2022-07-04T13:05:59Z
dc.date.issued2021
dc.identifier.citationMazzinari G., Serpa Neto A., Hemmes S., Hedenstierna G., Jaber S., Hiesmayr M., Wolmann M., Mills G., Çamcı A. E. , "The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study", BMC ANESTHESIOLOGY, cilt.21, sa.84, ss.1-15, 2021
dc.identifier.issn1471-2253
dc.identifier.otherav_39fadb51-a657-4f3d-a010-5e6898b092ee
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/182342
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/39fadb51-a657-4f3d-a010-5e6898b092ee/file
dc.identifier.urihttps://doi.org/10.1186/s12871-021-01268-y
dc.description.abstractAbstractBackground:It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTWwith intraoperative adverse events.Methods:Posthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events.Results:The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTWwas not different between groups. The association of ΔPTWwith PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTWwith intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12- to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001).Conclusions:ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery.
dc.language.isoeng
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectANESTEZİYOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectAnesteziyoloji
dc.subjectSurgery
dc.subjectAnesthesiology and Pain Medicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.titleThe Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study
dc.typeMakale
dc.relation.journalBMC ANESTHESIOLOGY
dc.contributor.department, ,
dc.identifier.volume21
dc.identifier.issue84
dc.identifier.startpage1
dc.identifier.endpage15
dc.contributor.firstauthorID3433188


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