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dc.contributor.authorTrabulus, Fadime Didem Can
dc.contributor.authorGÜVEN, MEHMET
dc.contributor.authorErhan, Duygu
dc.contributor.authorBATAR, BAHADIR
dc.contributor.authorOzoran, Emre
dc.date.accessioned2022-07-04T13:44:39Z
dc.date.available2022-07-04T13:44:39Z
dc.identifier.citationOzoran E., Trabulus F. D. C. , Erhan D., BATAR B., GÜVEN M., "Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer", INTERNATIONAL JOURNAL OF BREAST CANCER, cilt.2022, 2022
dc.identifier.issn2090-3170
dc.identifier.othervv_1032021
dc.identifier.otherav_574cf668-421c-4bd4-94d7-2d70910f0ba5
dc.identifier.urihttp://hdl.handle.net/20.500.12627/182840
dc.identifier.urihttps://doi.org/10.1155/2022/5817841
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/574cf668-421c-4bd4-94d7-2d70910f0ba5/file
dc.description.abstractBackground. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394) T (rs6869366) DNA repair and BAX G(-248) A (rs4645878), and BCL2 C(-938) A (rs2279115) apoptotic gene polymorphisms with breast cancer. Materials and Methods. Genetic analysis was performed using peripheral blood samples. Gene polymorphisms were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. 175 patients and 158 healthy controls were enrolled in the study. Results. Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248) A (rs4645878) (P=0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. The risk of breast cancer was 2.77 times more in individuals carrying the Met/Met genotype of XRCC3 Thr241Met (rs861539) (P=0.009). The risk of having advanced clinical stage (stage III+IV) with the Met/Met genotype was 4 times more increased. No relationship with breast cancer was found with XRCC4 G(-1394) T (rs6869366) and BCL2 C(-938) A (rs2279115) gene polymorphisms. Conclusion. Multicenter trials using subjects with genetic variations are needed to establish the relationship between breast cancer and single gene polymorphism.
dc.language.isoeng
dc.subjectOncology
dc.subjectHealth Sciences
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleAssociation of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF BREAST CANCER
dc.contributor.departmentAfyon Kocatepe Üniversitesi , ,
dc.identifier.volume2022
dc.contributor.firstauthorID3415450


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