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dc.contributor.authorÖZHAN, Gül
dc.contributor.authorAbudayyak, Mahmoud
dc.contributor.authorÖZTAŞ, Ezgi
dc.date.accessioned2022-07-04T14:00:26Z
dc.date.available2022-07-04T14:00:26Z
dc.date.issued2021
dc.identifier.citationAbudayyak M., ÖZTAŞ E., ÖZHAN G., "Determination of Perflourooctanoic Acid Toxicity in a Human Hepatocarcinoma Cell Line", Journal of Health and Pollution, cilt.11, sa.31, ss.1-13, 2021
dc.identifier.issn2156-9614
dc.identifier.othervv_1032021
dc.identifier.otherav_63c8dfa1-60c4-4984-884a-27b2f04b520e
dc.identifier.urihttp://hdl.handle.net/20.500.12627/183041
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/63c8dfa1-60c4-4984-884a-27b2f04b520e/file
dc.identifier.urihttps://doi.org/10.5696/2156-9614-11.31.210909
dc.description.abstract© Pure EarthBackground. Perfluorooctanoic acid (PFOA) is used in different industrial and commercial products. Research shows the presence of PFOA in home dusts, tap and surface water, and in biological samples. The International Agency for Research on Cancer (IARC) has classified PFOA as a possible carcinogen for humans. The liver is thought to be a target organ of PFOA accumulation and toxicity. Objective. Some studies have found toxic effects on the liver and related mechanisms; however, more studies are needed to better understand PFOA -induced hepatotoxicity. Methods. In the present study, a human hepatocarcinoma cell line was exposed to PFOA for 24 hours and cell viability, apoptosis, the oxidative system and immune response were evaluated. Results. While apoptosis was the main cell death pathway at low concentration (86.5%), the necrotic cell fraction increased with higher concentrations (46.7%). Significant changes in the reactive oxygen species (5.3-folds) glutathione (GSH) (1.7-folds) and catalase (CAT) (1.4-folds) levels were observed, as well as changes to interleukin-6 (≤1.8-fold) and interleukin-8 levels (35-40%). Conclusions. In light of the data, PFOA is potentially hepatotoxic through the investigated pathways. The results represent a background for future in vivo mechanistic studies. Competing Interests. The authors declare no competing financial interests.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMühendislik ve Teknoloji
dc.subjectPollution
dc.subjectPhysical Sciences
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectHealth Sciences
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectTOKSİKOLOJİ
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectYaşam Bilimleri
dc.subjectSosyal Bilimler (SOC)
dc.subjectMühendislik
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSosyal Bilimler Genel
dc.subjectMÜHENDİSLİK, ÇEVRE
dc.titleDetermination of Perflourooctanoic Acid Toxicity in a Human Hepatocarcinoma Cell Line
dc.typeMakale
dc.relation.journalJournal of Health and Pollution
dc.contributor.departmentKaradeniz Teknik Üniversitesi , ,
dc.identifier.volume11
dc.identifier.issue31
dc.identifier.startpage1
dc.identifier.endpage13
dc.contributor.firstauthorID3432074


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