dc.contributor.author | OKTAN, BURHANEDDİN | |
dc.contributor.author | AKKAN, Ahmet Gökhan | |
dc.contributor.author | Hussain, Adil | |
dc.contributor.author | Sonmez, Haktan | |
dc.contributor.author | Alagoz, Selma | |
dc.contributor.author | Kose, Cagla | |
dc.contributor.author | Sonmez, Ikbal | |
dc.contributor.author | BUKHARI, ANDLEEB | |
dc.date.accessioned | 2022-07-04T14:48:35Z | |
dc.date.available | 2022-07-04T14:48:35Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | BUKHARI A., Sonmez I., Kose C., OKTAN B., Alagoz S., Sonmez H., Hussain A., AKKAN A. G. , "The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit", MEDICINA-LITHUANIA, cilt.58, sa.2, 2022 | |
dc.identifier.issn | 1010-660X | |
dc.identifier.other | av_8f115c7e-ff43-418c-b387-9420ea655f8e | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/183708 | |
dc.identifier.uri | https://doi.org/10.3390/medicina58020183 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/8f115c7e-ff43-418c-b387-9420ea655f8e/file | |
dc.description.abstract | Background and Objectives: Chronic kidney disease (CKD) is usually linked with polypharmacy and patients are invariably at risk of complex medication regimens. The present study was designed to estimate the potential drug-drug interactions (pDDIs) through the prescription patterns provided to patients of the Nephrology Transplant Unit of Cerrahpasa Medical Faculty patients. Materials and Methods: 96 patients were included in the study. pDDIs among every combination of the prescribed drug were analyzed using the Thomson Reuters Micromedex. Results: We found 149 pDDIs making 2.16 interactions per prescription with incidence rates of 69.7%. Approximately 4.1% of interactions were of significant severity, 75.1% moderate severity, and 20.8% were classified as minor pDDIs. The most frequent interactions were found between iron and aluminum, calcium or magnesium-containing products (21.37%), calcium channel blockers and beta-blockers (8.96%); and aspirin and aluminum, calcium, or magnesium-containing products (7.58%). We identified 42 drug pairs with probability of clinical significance. The most commonly reported clinical outcomes of the pDDIs were hypo- or hypertension (39.24%), decreased drug efficacy (24.05%), and arrhythmia (9.49%). Aluminum, calcium, or magnesium-containing drug products (33.10%) constituted the primary class of drugs involved in interactions. Conclusions: This study showed pharmacodynamics (49%), pharmacokinetics (42.94%) interactions, polypharmacy and gender as determinant of pDDIs. A comprehensive multicenter research is required to decrease the morbidity and ease the state burden. | |
dc.language.iso | eng | |
dc.subject | Pathophysiology | |
dc.subject | Assessment and Diagnosis | |
dc.subject | Medicine (miscellaneous) | |
dc.subject | General Medicine | |
dc.subject | Health Sciences | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Family Practice | |
dc.subject | Fundamentals and Skills | |
dc.subject | General Health Professions | |
dc.subject | Internal Medicine | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.title | The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit | |
dc.type | Makale | |
dc.relation.journal | MEDICINA-LITHUANIA | |
dc.contributor.department | İstanbul Üniversitesi-Cerrahpaşa , , | |
dc.identifier.volume | 58 | |
dc.identifier.issue | 2 | |
dc.contributor.firstauthorID | 3401720 | |