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dc.contributor.authorBAYOĞLU, BURCU
dc.contributor.authorİPEK, GÖKHAN
dc.contributor.authorArslan, Caner
dc.contributor.authorGÖKSEDEF, DENİZ
dc.contributor.authorRecep, Eymen
dc.date.accessioned2022-07-04T14:52:20Z
dc.date.available2022-07-04T14:52:20Z
dc.identifier.citationRecep E., BAYOĞLU B., Arslan C., GÖKSEDEF D., İPEK G., "Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery", TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2022
dc.identifier.issn0250-4685
dc.identifier.othervv_1032021
dc.identifier.otherav_91a95aa2-eb29-4073-a430-372325b7f3d3
dc.identifier.urihttp://hdl.handle.net/20.500.12627/183758
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/91a95aa2-eb29-4073-a430-372325b7f3d3/file
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0214
dc.description.abstractObjectives Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis. Methods In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR. Results The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Furthermore, logistic regression analysis revealed significant associations between the three variants and the risk factors for CAD development, namely waist circumference (p=0.002), body mass index (p=0.013), fasting glucose level (p=0.006), and triglyceride levels (p=0.035). Conclusions OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants do not increase the risk for CAD development. However, this conclusion should be confirmed with a larger cohort.
dc.language.isoeng
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectLife Sciences
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectSitogenetik
dc.titleRoles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery
dc.typeMakale
dc.relation.journalTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , ,
dc.contributor.firstauthorID3423681


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