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dc.contributor.authorCelik, Elif
dc.contributor.authorSahin, Umut
dc.contributor.authorGeorgiadou, Panagiota
dc.contributor.authorSutlu, Tolga
dc.contributor.authorTABAK, ÖMER FEHMİ
dc.contributor.authorMETE, BİLGÜL
dc.contributor.authorPekbilir, Emre
dc.contributor.authorBATU OTO, Bilge
dc.date.accessioned2022-07-04T15:11:25Z
dc.date.available2022-07-04T15:11:25Z
dc.date.issued2022
dc.identifier.citationMETE B., Pekbilir E., BATU OTO B., Georgiadou P., Celik E., Sutlu T., TABAK Ö. F. , Sahin U., "Human immunodeficiency virus type 1 impairs sumoylation", LIFE SCIENCE ALLIANCE, cilt.5, sa.6, 2022
dc.identifier.issn2575-1077
dc.identifier.othervv_1032021
dc.identifier.otherav_a1c20bae-1a35-41f5-8a5a-e60b2e73fd3a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/184015
dc.identifier.urihttps://doi.org/10.26508/lsa.202101103
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/a1c20bae-1a35-41f5-8a5a-e60b2e73fd3a/file
dc.description.abstractDuring infection, the human immunodeficiency virus type 1 (HIV-1) manipulates host cell mechanisms to its advantage, thereby controlling its replication or latency, and evading immune responses. Sumoylation is an essential post-translational modification that controls vital cellular activities including proliferation, sternness, or anti-viral immunity. SUMO peptides oppose pathogen replication and mediate interferon-dependent anti-viral activities. In turn, several viruses and bacteria attack sumoylation to disarm host immune responses. Here, we show that HIV-1 impairs cellular sumoylation and targets the host SUMO E1-activating enzyme. HIV-1 expression in cultured HEK293 cells or in CD4(+) Jurkat T lymphocytes diminishes sumoylation by both SUMO paralogs, SUMO1 and SUMO2/3. HIV-1 causes a sharp and specific decline in UBA2 protein levels, a subunit of the heterodimeric SUMO E1 enzyme, which likely serves to reduce the efficiency of global protein sumoylation. Furthermore, HIV-1-infected individuals display a significant reduction in total leukocyte sumoylation that is uncoupled from HIV-induced cytopenia. Because sumoylation is vital for immune function, T-cell expansion and activity, loss of sumoylation during HIV disease may contribute to immune system deterioration in patients.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectHealth Sciences
dc.subjectYaşam Bilimleri
dc.subjectBiochemistry (medical)
dc.subjectBİYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTıbbi Biyoloji
dc.titleHuman immunodeficiency virus type 1 impairs sumoylation
dc.typeMakale
dc.relation.journalLIFE SCIENCE ALLIANCE
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Cerrahpaşa Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume5
dc.identifier.issue6
dc.contributor.firstauthorID3403377


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