dc.contributor.author | Kokturk, Sibel | |
dc.contributor.author | CIRRIK, SELMA | |
dc.contributor.author | ÇETİNKOL, YELİZ | |
dc.date.accessioned | 2022-07-04T15:11:38Z | |
dc.date.available | 2022-07-04T15:11:38Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kokturk S., ÇETİNKOL Y., CIRRIK S., "Crinum latifolium extract inhibits lipopolysaccharide-induced inflammation in human macrophages", REVISTA ROMANA DE MEDICINA DE LABORATOR, cilt.30, sa.2, ss.183-190, 2022 | |
dc.identifier.issn | 1841-6624 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_a24b7d74-4f9e-4d74-b7ba-23084888ed48 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/184021 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/a24b7d74-4f9e-4d74-b7ba-23084888ed48/file | |
dc.identifier.uri | https://doi.org/10.2478/rrlm-2022-0015 | |
dc.description.abstract | Introduction: Crinum latifolium is a natural plant showing the anti-inflammatory effects. We aimed to evaluate the effects of Crinum latifolium extract on proinflammatory cytokine production and maturation of early and late endosomes in the lipopolysaccharide (LPS)-induced human macrophages at light microscopic and biochemical levels. Material and Methods: The effects of Crinum latifolium extract in human macrophages stimulated with LPS was evaluated to optic densities of the lysosome-associated membrane protein-1 (LAMP-1) and early endo-some antigen 1 (EEA1) by immunohistochemistry staining and to level of the proinflammatory cytokine interleukin (IL)-6 by enzyme-linked immunosorbent assay (ELISA). Results: Crinum latifolium group exhibited a significant decreased in the levels of IL-6 in the supernatant as compared to the LPS group for 2 and 72 hours (p<0.0001). Crinum latifolium group exhibited a significant increased in the optic density of the EEA1 and LAMP-1 in coverslips as compared to the control and lipopolysaccharide groups after 2 and 72 hours (p<0.0001). Conclusions: Crinum latifolium may a therapeutic plant in the inflammatory diseases, such as sepsis, through anti-inflammatory effects, such as decrease in production of the proinflammatory cytokine and increase in maturations of the early and late endosomes in macrophages. | |
dc.language.iso | eng | |
dc.subject | Health Sciences | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Research and Theory | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Reviews and References (medical) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.title | Crinum latifolium extract inhibits lipopolysaccharide-induced inflammation in human macrophages | |
dc.type | Makale | |
dc.relation.journal | REVISTA ROMANA DE MEDICINA DE LABORATOR | |
dc.contributor.department | İstanbul Üniversitesi , İstanbul Tıp Fakültesi , Temel Tıp Bilimleri Bölümü | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 183 | |
dc.identifier.endpage | 190 | |
dc.contributor.firstauthorID | 3422159 | |