dc.contributor.author | Sezer, Siren | |
dc.contributor.author | Demirkaya, Erkan | |
dc.contributor.author | Yilmaz, Ilker | |
dc.contributor.author | Poddighe, Dimitri | |
dc.contributor.author | KASAPÇOPUR, ÖZGÜR | |
dc.contributor.author | Appleton, C. Thomas | |
dc.contributor.author | ŞAHİN, SEZGİN | |
dc.contributor.author | Romano, Micol | |
dc.contributor.author | Guzel, Ferhat | |
dc.contributor.author | Piskin, David | |
dc.date.accessioned | 2022-07-04T15:18:36Z | |
dc.date.available | 2022-07-04T15:18:36Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | ŞAHİN S., Romano M., Guzel F., Piskin D., Poddighe D., Sezer S., KASAPÇOPUR Ö., Appleton C. T. , Yilmaz I., Demirkaya E., "Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene", LIFE-BASEL, cilt.12, sa.5, 2022 | |
dc.identifier.issn | 2075-1729 | |
dc.identifier.other | av_a903f69e-3a4b-4bc5-a9b9-c6e13c7df9d2 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/184137 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/a903f69e-3a4b-4bc5-a9b9-c6e13c7df9d2/file | |
dc.identifier.uri | https://doi.org/10.3390/life12050631 | |
dc.description.abstract | Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ between the two groups apart from arthritis (76.3% in Group 1 and 59.1% in Group 2, p < 0.05). FMD was significantly lower in Group 1 when compared with Group 2 (MD [95% CI]: -0.6 [(-0.89)-(-0.31)]). cIMT, FGF23, and PTX3 levels were higher in Group 1 (cIMT MD [95% CI]: 0.12 [0.08-0.16]; FGF23 MD [95% CI]: 12.8 [5.9-19.6]; PTX3 MD [95% CI]: 13.3 [8.9-17.5]). In patients with FMF-AA, M694V homozygosity is associated with lower FMD values and higher cIMT, FGF23, and PTX3 levels, suggesting increased CVD risk profiles. These data suggest that a genotype-phenotype association exists in terms of endothelial dysfunction and atherosclerosis in patients with FMF-AA. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Biochemistry (medical) | |
dc.subject | Health Sciences | |
dc.subject | Tıbbi Biyoloji | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | BİYOLOJİ | |
dc.subject | Mikrobiyoloji | |
dc.subject | Biyokimya | |
dc.title | Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene | |
dc.type | Makale | |
dc.relation.journal | LIFE-BASEL | |
dc.contributor.department | İstanbul Üniversitesi-Cerrahpaşa , Cerrahpaşa Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 5 | |
dc.contributor.firstauthorID | 3433713 | |