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dc.contributor.authorMorosını, Marıa Isabel
dc.contributor.authorAbulaıla, Ayham
dc.contributor.authorÖncül, Mustafa Oral
dc.contributor.authorCanton, Rafael
dc.contributor.authorErdem, Fatma
dc.contributor.authorAguılar, Marıa Dıez
dc.contributor.authorÖksüz, Lütfiye
dc.contributor.authorKayacan, Zeynep Çiğdem
dc.contributor.authorAktaş, Zerrin
dc.date.accessioned2022-07-04T15:39:35Z
dc.date.available2022-07-04T15:39:35Z
dc.date.issued2022
dc.identifier.citationErdem F., Aguılar M. D. , Öksüz L., Kayacan Z. Ç. , Abulaıla A., Öncül M. O. , Morosını M. I. , Canton R., Aktaş Z., "Time kill-assays of antibiotic combinations for multidrug resistant clinical isolates of OXA-48 carbapenemase producing Klebsiella pneumoniae", ACTA MICROBIOLOGICA ET IMMUNOLOGICA, cilt.69, sa.3, ss.1-5, 2022
dc.identifier.issn1217-8950
dc.identifier.othervv_1032021
dc.identifier.otherav_bbecbc8b-fa98-43bf-8918-5b1a156aba0f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/184444
dc.identifier.urihttps://doi.org/10.1556/030.2022.01785
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/bbecbc8b-fa98-43bf-8918-5b1a156aba0f/file
dc.description.abstractABSTRACTTreatment of infections caused by OXA-48 carbapenemase producing multidrug-resistant isolates often necessitates combination therapy. In vitro effect of different antibiotic combinations against multidrugresistant (MDR) Klebsiella pneumoniae isolates were evaluated in this study.Meropenem-tobramycin (MERþTOB), meropenem-ciprofloxacin (MERþCIP), colistin-meropenem( COLþMER), colistin-ciprofloxacin (COLþCIP) and colistin-tobramycin (COLþTOB) combinations were tested by time kill-assays. Each antibiotic alone and in combination at their Cmax values were tested against 4 clinical K. pneumoniae isolates at 1, 2, 4, 6, 8, 12 and 24 h. Effect of colistin and its associations were also assessed at 30 min. Bactericidal activity was defined as ≥3log10 CFU mL1 decrease compared with initial inoculum. Synergy was defined as ≥2log10CFU mL1 decrease by the combination compared with the most active single agent. Presence of blaOXA-48, blaNDM, blaVIM, blaIMP, blaKPC and blaCTX-M-1 genes was screened by PCR using specific primers. The blaOXA-48 gene was identified together with blaCTXM-1 group gene in all isolates. COLþMER demonstrated to be synergistic and bactericidal. MERþTOB showed synergistic and bactericidal effect on two strains although, regrowth was seen on other two strains at 24 h. MERþCIP exhibited indifferent effect on the strains.Combination therapy could be a potential alternative to treat MDR K.pneumoniae infections. This combination might prevent resistance development and secondary effects of colistin monotherapy. MERþTOB and MERþCIP might have an isolate-dependent effect, that may not always result in synergism.
dc.language.isoeng
dc.subjectHealth Sciences
dc.subjectGeneral Health Professions
dc.subjectTıbbi Mikrobiyoloji
dc.subjectImmunology and Microbiology (miscellaneous)
dc.subjectMicrobiology
dc.subjectFamily Practice
dc.subjectMicrobiology (medical)
dc.subjectFundamentals and Skills
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectPathophysiology
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectMikrobiyoloji
dc.subjectTIP, GENEL & İÇECEK
dc.subjectMİKROBİYOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectInternal Medicine
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectLife Sciences
dc.titleTime kill-assays of antibiotic combinations for multidrug resistant clinical isolates of OXA-48 carbapenemase producing Klebsiella pneumoniae
dc.typeMakale
dc.relation.journalACTA MICROBIOLOGICA ET IMMUNOLOGICA
dc.contributor.departmentADANA EĞİTİM ARAŞTIRMA HASTANESİ , ,
dc.identifier.volume69
dc.identifier.issue3
dc.identifier.startpage1
dc.identifier.endpage5
dc.contributor.firstauthorID3434157


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