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dc.contributor.authorPehlivan, Sacide
dc.contributor.authorTukek, Tufan
dc.contributor.authorOyaci, Yasemin
dc.contributor.authorAlkac, Ummuhan Isoglu
dc.date.accessioned2022-07-04T16:25:12Z
dc.date.available2022-07-04T16:25:12Z
dc.identifier.citationTukek T., Pehlivan S., Oyaci Y., Alkac U. I. , "Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family", GLOBAL MEDICAL GENETICS, 2022
dc.identifier.issn2699-9404
dc.identifier.otherav_e455b100-cf75-4f4e-9f0a-b3565c1653c9
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185106
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/e455b100-cf75-4f4e-9f0a-b3565c1653c9/file
dc.identifier.urihttps://doi.org/10.1055/s-0042-1743258
dc.description.abstractMannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19.
dc.language.isoeng
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectGenetics
dc.subjectMolecular Biology
dc.subjectGenetics (clinical)
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectGENETİK VE HAYAT
dc.subjectDahili Tıp Bilimleri
dc.titleMannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
dc.typeMakale
dc.relation.journalGLOBAL MEDICAL GENETICS
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.contributor.firstauthorID3397833


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