Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study
Date
2022Author
KOCAZEYBEK, BEKİR SAMİ
DİNÇ, HARİKA ÖYKÜ
Demirci, Mehmet
Ozdemir, Yusuf Emre
Sirekbasan, Serhat
Aktas, Ayse Nur
KARAALİ, RIDVAN
TOK, YEŞİM
Ozbey, Dogukan
Akcin, Ruveyda
Gareayaghi, Nesrin
Kuskucu, Mert Ahmet
MİDİLLİ, KENAN
AYGÜN, GÖKHAN
Saribas, Suat
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Background: Monitoring the longevity of immunoglobulin G (IgG) responses following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections is vital to understanding the role of antibodies in preventing infection. Aims: To determine the quantitative IgG responses specific to the Spike-S1 (S1) receptor-binding domain (S1/RBD) region of the virus in serum samples taken between 4 weeks and 7 months after polymerase chain reaction (PCR) positivity in patients who are diagnosed with coronavirus disease-2019 (COVID-19). Study Design: A longitudinal study. Methods: This study included 113 patients with a clinical and molecular diagnosis of COVID-19. The first and second serum samples were taken 1 and 7 months, respectively, after the PCR positivity. S1/ RBD-specific IgG antibody response was assayed using anti-SARS-CoV-2 QuantiVac ELISA (IgG) kit (Euroimmun, Lubeck, Germany). The neutralizing antibodies were investigated in 57 patients whose IgG test results were above the cut-off value. Results: In 57 patients with SARS-CoV-2 IgG, the anti-SARS-CoV-2 IgG quantitative antibody levels significantly decreased after 7 months (Z = -2.197, p = 0.028). A correlation was detected between the anti-SARS-CoV-2 IgG and nAb percent inhibition (IH%) levels detected in 1 month (rs = 0.496, p 6 months). Due to the limited information on seroconversion, comprehensive studies should be conducted for long-term follow-up of the immune response against SARS-CoV-2.
URI
http://hdl.handle.net/20.500.12627/185209https://doi.org/10.4274/balkanmedj.galenos.2022.2021-8-131
https://avesis.istanbul.edu.tr/api/publication/ea64c9e0-fdae-49e8-8efc-9f9a0cfe4504/file
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