dc.contributor.author | KOCAZEYBEK, BEKİR SAMİ | |
dc.contributor.author | DİNÇ, HARİKA ÖYKÜ | |
dc.contributor.author | Demirci, Mehmet | |
dc.contributor.author | Ozdemir, Yusuf Emre | |
dc.contributor.author | Sirekbasan, Serhat | |
dc.contributor.author | Aktas, Ayse Nur | |
dc.contributor.author | KARAALİ, RIDVAN | |
dc.contributor.author | TOK, YEŞİM | |
dc.contributor.author | Ozbey, Dogukan | |
dc.contributor.author | Akcin, Ruveyda | |
dc.contributor.author | Gareayaghi, Nesrin | |
dc.contributor.author | Kuskucu, Mert Ahmet | |
dc.contributor.author | MİDİLLİ, KENAN | |
dc.contributor.author | AYGÜN, GÖKHAN | |
dc.contributor.author | Saribas, Suat | |
dc.date.accessioned | 2022-07-04T16:32:28Z | |
dc.date.available | 2022-07-04T16:32:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | DİNÇ H. Ö. , Demirci M., Ozdemir Y. E. , Sirekbasan S., Aktas A. N. , KARAALİ R., TOK Y., Ozbey D., Akcin R., Gareayaghi N., et al., "Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study", BALKAN MEDICAL JOURNAL, cilt.39, sa.3, ss.172-177, 2022 | |
dc.identifier.issn | 2146-3123 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_ea64c9e0-fdae-49e8-8efc-9f9a0cfe4504 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/185209 | |
dc.identifier.uri | https://doi.org/10.4274/balkanmedj.galenos.2022.2021-8-131 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/ea64c9e0-fdae-49e8-8efc-9f9a0cfe4504/file | |
dc.description.abstract | Background: Monitoring the longevity of immunoglobulin G (IgG) responses following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections is vital to understanding the role of antibodies in preventing infection. Aims: To determine the quantitative IgG responses specific to the Spike-S1 (S1) receptor-binding domain (S1/RBD) region of the virus in serum samples taken between 4 weeks and 7 months after polymerase chain reaction (PCR) positivity in patients who are diagnosed with coronavirus disease-2019 (COVID-19). Study Design: A longitudinal study. Methods: This study included 113 patients with a clinical and molecular diagnosis of COVID-19. The first and second serum samples were taken 1 and 7 months, respectively, after the PCR positivity. S1/ RBD-specific IgG antibody response was assayed using anti-SARS-CoV-2 QuantiVac ELISA (IgG) kit (Euroimmun, Lubeck, Germany). The neutralizing antibodies were investigated in 57 patients whose IgG test results were above the cut-off value. Results: In 57 patients with SARS-CoV-2 IgG, the anti-SARS-CoV-2 IgG quantitative antibody levels significantly decreased after 7 months (Z = -2.197, p = 0.028). A correlation was detected between the anti-SARS-CoV-2 IgG and nAb percent inhibition (IH%) levels detected in 1 month (rs = 0.496, p 6 months). Due to the limited information on seroconversion, comprehensive studies should be conducted for long-term follow-up of the immune response against SARS-CoV-2. | |
dc.language.iso | eng | |
dc.subject | Internal Medicine | |
dc.subject | Medicine (miscellaneous) | |
dc.subject | General Medicine | |
dc.subject | Health Sciences | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Family Practice | |
dc.subject | Fundamentals and Skills | |
dc.subject | General Health Professions | |
dc.subject | Pathophysiology | |
dc.subject | Assessment and Diagnosis | |
dc.title | Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study | |
dc.type | Makale | |
dc.relation.journal | BALKAN MEDICAL JOURNAL | |
dc.contributor.department | Bezmiâlem Vakıf Üniversitesi , Eczacılık Fakültesi , Temel Eczacılık Bilimleri Bölümü | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 172 | |
dc.identifier.endpage | 177 | |
dc.contributor.firstauthorID | 3433596 | |