Show simple item record

dc.contributor.authorOnur, Seda Tural
dc.contributor.authorKara, Kaan
dc.contributor.authorADEMOĞLU, Evin
dc.contributor.authorOzdemir, Cengiz
dc.contributor.authorKahya, Ozlem
dc.contributor.authorSokucu, Sinem Nedime
dc.date.accessioned2022-07-04T16:38:59Z
dc.date.available2022-07-04T16:38:59Z
dc.date.issued2022
dc.identifier.citationKara K., Onur S. T. , Sokucu S. N. , Kahya O., Ozdemir C., ADEMOĞLU E., "The Role of Serum Galectin-3 Levels in Patients with Sarcoidosis", MEDICAL PRINCIPLES AND PRACTICE, cilt.31, sa.1, ss.59-65, 2022
dc.identifier.issn1011-7571
dc.identifier.otherav_f0001ec0-4a08-4807-8da9-b21eb2524d52
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185305
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/f0001ec0-4a08-4807-8da9-b21eb2524d52/file
dc.identifier.urihttps://doi.org/10.1159/000521467
dc.description.abstractIntroduction: Galectin-3 is a multifunctional protein, the levels of which increase in the presence of diseases that progress with pulmonary fibrosis. This study investigated the role of galectin-3 levels in the staging and assessing of the severity of sarcoidosis. Methods and Subjects: Seventy-three subjects were studied; 25 were healthy individuals and 48 patients had pathologically confirmed diagnosis of sarcoidosis in which other potential causes had been ruled out. Galectin-3 levels were measured and compared in terms of such parameters as hemogram, biochemistry, age, body mass index, and smoking status. Results: The mean galectin-3 levels of the sarcoidosis patients (14.87 +/- 5.57) were significantly higher than those in the healthy subjects (11.81 +/- 2.67), and the mean galectin-3 levels differed significantly among different stages of the disease (p < 0.05). The serum galectin-3 level in patients with stage 2, 3, and 4 sarcoidosis was found to be higher than in patients with stage 0 and 1 sarcoidosis and the control group. In addition, serum galectin-3 levels in the sarcoidosis patients had significant positive correlations with blood urea nitrogen, alkaline phosphatase, white blood cells, red blood cell, hemoglobin, and neutrophil levels (34.9% [p < 0.05]; 40.1% [p < 0.05]; 41.2% [p < 0.01]; 43.3% [p < 0.01]; 34.7% [p < 0.05]; and 40.6% [p < 0.01], respectively) and a significant negative correlation with the platelet distribution width levels (p < 0.05). Conclusion: Serum galectin-3 levels are significantly elevated in sarcoidosis patients with parenchymal involvement at stage 2 or higher, suggesting that serum galectin-3 levels can be used to estimate disease severity in sarcoidosis. (C) 2021 The Author(s) Published by S. Karger AG, Basel
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectFamily Practice
dc.subjectGeneral Health Professions
dc.subjectKlinik Tıp (MED)
dc.subjectHealth Sciences
dc.subjectGeneral Medicine
dc.subjectMedicine (miscellaneous)
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectPathophysiology
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectFundamentals and Skills
dc.titleThe Role of Serum Galectin-3 Levels in Patients with Sarcoidosis
dc.typeMakale
dc.relation.journalMEDICAL PRINCIPLES AND PRACTICE
dc.contributor.departmentYedikule Chest Dis & Chest Surg Training & Res Ho , ,
dc.identifier.volume31
dc.identifier.issue1
dc.identifier.startpage59
dc.identifier.endpage65
dc.contributor.firstauthorID3425285


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record