Basit öğe kaydını göster

dc.contributor.authorKaradag, Serife G.
dc.contributor.authorSozeri, Betul
dc.contributor.authorCakan, Mustafa
dc.contributor.authorOzdel, Semanur
dc.contributor.authorAyaz, Nuray
dc.contributor.authorDemir, Ferhat
dc.contributor.authorSÖNMEZ, HAFİZE EMİNE
dc.contributor.authorBaglan, Esra
dc.contributor.authorAKGÜN, Özlem
dc.contributor.authorCoskuner, Taner
dc.contributor.authorYener, Gulcin Otar
dc.contributor.authorOzturk, Kubra
dc.date.accessioned2022-07-04T16:42:51Z
dc.date.available2022-07-04T16:42:51Z
dc.identifier.citationDemir F., SÖNMEZ H. E. , Baglan E., AKGÜN Ö., Coskuner T., Yener G. O. , Ozturk K., Cakan M., Karadag S. G. , Ozdel S., et al., "Cluster analysis of paediatric Behcet's disease: Data from The Pediatric Rheumatology Academy-Research Group", MODERN RHEUMATOLOGY, 2022
dc.identifier.issn1439-7595
dc.identifier.othervv_1032021
dc.identifier.otherav_f4123d5d-2648-4565-9539-3e407a8497eb
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185376
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/f4123d5d-2648-4565-9539-3e407a8497eb/file
dc.identifier.urihttps://doi.org/10.1093/mr/roac044
dc.description.abstractObjectives Behcet's disease (BD) is a systemic vasculitis affecting many organ systems, with the involvement of all-sized arteries and veins. The study aims to determine the main characteristics of paediatric BD patients and also analyse the clustering phenotypes. Methods Demographic data, clinical manifestations, laboratory features, treatment schedules, and disease outcomes were achieved from patients' charts retrospectively. A cluster analysis was performed according to the phenotype. Results A total of 225 (109 male/116 female) patients with BD were enrolled in the study. The median ages of disease onset and diagnosis were 131 (36-151) and 156 (36-192) months, respectively. According to cluster analysis, 132 (58.6%) patients belonged to the mucocutaneous-only cluster (C1), while 35 (15.6%) patients fitted to articular type (C2), 25 (11.1%) were in the ocular cluster (C3), 26 (11.6%) were in the vascular cluster (C4), and 7(3.1%) belonged to the gastrointestinal cluster (C5). Ocular and vascular clusters were more common in boys (p < .001), while girls usually presented with the mucocutaneous-only cluster. The disease activity at the diagnosis and the last control was higher in ocular, vascular, and gastrointestinal clusters. Conclusions These identified juvenile BD clusters express different phenotypes with different outcomes Our analysis may help clinicians to identify the disease subtypes accurately and to arrange personalized treatment.
dc.language.isoeng
dc.subjectRheumatology
dc.subjectHealth Sciences
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectROMATOLOJİ
dc.subjectDahili Tıp Bilimleri
dc.titleCluster analysis of paediatric Behcet's disease: Data from The Pediatric Rheumatology Academy-Research Group
dc.typeMakale
dc.relation.journalMODERN RHEUMATOLOGY
dc.contributor.departmentAcibadem Healthcare Grp , ,
dc.contributor.firstauthorID3432612


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster