Show simple item record

dc.contributor.authorUzun, Hafize
dc.contributor.authorSafran, Nurhas
dc.contributor.authorAhişalı, Bülent
dc.contributor.authorMercanoğlu, Habibe Güldem
dc.date.accessioned2023-02-21T07:24:37Z
dc.date.available2023-02-21T07:24:37Z
dc.identifier.citationMercanoğlu H. G., Safran N., Ahişalı B., Uzun H., "PP081 Nitic Oxide Mediated Effects of Nebivolol in Myocardial Infarction: The Source of Nitric Oxide ", XXI World Congress of Echocardiograpy and Cardiolgy, İstanbul, Türkiye, 20 - 22 Kasım 2015, ss.39
dc.identifier.othervv_1032021
dc.identifier.otherav_05dc41a6-ef0a-4a4a-91bd-94264fc13786
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185769
dc.identifier.urihttps://www.researchgate.net/publication/284190139
dc.description.abstractObjective: After MI, LV remodelling is one of the major causes of death. We previously showed the NO mediated beneficial effects of nebivolol in rat MI model, in this study we aimed to determine the source of NO. Methods: Rats were divided into four groups: sham operated (sham-control), MI-induced (MI-control), immediate nebivolol loaded (MI-neb1), orally nebivolol treated (MI-neb2). MI was induced by the ligation of the LAD. NOS related mechanisms were assessed either in acute and sub-acute period of MI by histologic, hemodynamic and biologic studies. Results: Compared to MI-control rats, physiological functions of LV (LVEDP, D!dp/dt) were prevented in nebivolol treated groups. Improvements in anatomical parameters (LEV, HW, LVW/HW) were consistent with functional improvement. Oxidative (decreased MDA, increased SOD) and nitrosative (decreased ONOO-) damage were limited also. Most dramatic change was seen in the nNOS labelling.The decrease in iNOS labelling was also prominent too. Conclusions: NOS mediated mechanisms of nebivolol can be summarized as: 1) diminishing iNOS expression together with restoration of MI induced eNOS activation both in vascular bed and myocytes at the acute period of MI, and 2) prevention of deterioration in nNOS expression in myocardial cells at the sub-acute period of MI.
dc.language.isotur
dc.subjectSağlık Bilimleri
dc.subjectKlinik Tıp (MED)
dc.titlePP081 Nitic Oxide Mediated Effects of Nebivolol in Myocardial Infarction: The Source of Nitric Oxide
dc.typeBildiri
dc.contributor.departmentYeditepe Üniversitesi , Eczacılık Fakültesi , Temel Eczacılık Bilimleri Bölümü
dc.contributor.firstauthorID3453268


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record