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dc.contributor.authorZvarych, Viktor
dc.contributor.authorStasevych, Maryna
dc.contributor.authorNesterkina, Mariia
dc.contributor.authorKravchenko, Iryna
dc.contributor.authorAYDINLI, SERDAR GÖKŞİN
dc.contributor.authorBulut, Elif
dc.contributor.authorDENİZ, NAHİDE GÜLŞAH
dc.contributor.authorSAYIL, MAKBULE ÇİĞDEM
dc.contributor.authorKomarovska-Porokhnyavets, Olena
dc.contributor.authorLubenets, Vira
dc.date.accessioned2023-02-21T07:48:40Z
dc.date.available2023-02-21T07:48:40Z
dc.date.issued2022
dc.identifier.citationAYDINLI S. G., Bulut E., DENİZ N. G., SAYIL M. Ç., Komarovska-Porokhnyavets O., Lubenets V., Zvarych V., Stasevych M., Nesterkina M., Kravchenko I., "New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities", CHEMISTRY & BIODIVERSITY, cilt.19, sa.7, 2022
dc.identifier.issn1612-1872
dc.identifier.otherav_0e059712-e444-4588-a4b7-a4ac5f4b9966
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186126
dc.identifier.urihttps://doi.org/10.1002/cbdv.202100931
dc.description.abstractThe ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene-N,S,S-acetals and S,S,S-acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatographic methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives 4e and 5h, which have MIC=15.6 mu g/mL for the test culture of Mycobacterium luteum bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future molecular design to enhance the antimicrobial action. Ketene dithioacetals 3, 4a, 4b, 4e, 5g (50 mg/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole-induced convulsions after single oral administration both at 3 h and 24 h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals.
dc.language.isoeng
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.titleNew Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
dc.typeMakale
dc.relation.journalCHEMISTRY & BIODIVERSITY
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Mühendislik Fakültesi , Kimya Bölümü
dc.identifier.volume19
dc.identifier.issue7
dc.contributor.firstauthorID3435082


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