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dc.contributor.authorCavak, Nensi
dc.contributor.authorDEMİRCİ ÇEKİÇ, SEMA
dc.contributor.authorGÜMÜŞTAŞ, MUSTAFA KORAY
dc.date.accessioned2023-02-21T08:31:14Z
dc.date.available2023-02-21T08:31:14Z
dc.date.issued2022
dc.identifier.citationCavak N., GÜMÜŞTAŞ M. K., DEMİRCİ ÇEKİÇ S., "The Protective Role of Hippophae rhamnoides L. on Rat Brain and Liver Tissues Exposed to Cold Plus Immobilization Stress Model", TURKISH NEUROSURGERY, cilt.32, sa.4, ss.587-594, 2022
dc.identifier.issn1019-5149
dc.identifier.otherav_1c3c4f97-76ff-484d-8cfb-d2679c99ae4b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186737
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/1c3c4f97-76ff-484d-8cfb-d2679c99ae4b/file
dc.identifier.urihttps://doi.org/10.5137/1019-5149.jtn.23766-18.3
dc.description.abstractAIM: To investigate the protective role of Hippophae rhamnoides L. (Sea buckthorn, SBT) in cold plus immobilization stress-induced oxidative and nitrosative stress in rats. MATERIAL and METHODS: Thirty-two Wistar albino rats were randomly divided into four groups: control (i.p. physiological saline), SBT (i.p. 200 mg/kg/48h SBT extract), stress (i.p. physiological saline; 6-h cold plus immobilization stress) and SBT+stress (i.p. 200 mg/kg/48h SBT; 6-h cold plus immobilization stress).* In liver and brain tissues 3-nitrotyrosine levels were determined by ELISA while total antioxidant capacity, total thiol, total glutathione, total nitrite+nitrate levels, superoxide dismutase and glutathione peroxidase activities were measured using colorimetric methods. RESULTS: In the SBT+stress group, the total glutathione levels and glutathione peroxidase activities were significantly higher in both tissues, whereas the total nitrite+nitrate levels and superoxide dismutase activities decreased compared with the stress group. The 3-nitrotyrosine levels as oxidative and nitrosative stress markers were found to be significantly higher in SBT+stress group in both tissues than in the control. No significant differences were found between the stress and SBT+stress groups in the liver. CONCLUSION: The results show that SBT has antioxidant properties against cold plus immobilization stress-induced oxidative and nitrosative stress and that it can be recommended as a natural antioxidant and nutritional supplement.
dc.language.isoeng
dc.subjectCerrahi
dc.subjectNöroloji (klinik)
dc.subjectYaşam Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectCERRAHİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NÖROLOJİ
dc.titleThe Protective Role of Hippophae rhamnoides L. on Rat Brain and Liver Tissues Exposed to Cold Plus Immobilization Stress Model
dc.typeMakale
dc.relation.journalTURKISH NEUROSURGERY
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , ,
dc.identifier.volume32
dc.identifier.issue4
dc.identifier.startpage587
dc.identifier.endpage594
dc.contributor.firstauthorID3450091


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