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dc.contributor.authorCagatay, Atahan
dc.contributor.authorOzsut, Halit
dc.contributor.authorSimsek-Yavuz, Serap
dc.contributor.authorGül, Ahmet
dc.contributor.authorEraksoy, Haluk
dc.contributor.authorBasaran, Seniha
dc.contributor.authorBenli, Aysun
dc.contributor.authorTor, Yavuz Burak
dc.date.accessioned2023-02-21T09:10:22Z
dc.date.available2023-02-21T09:10:22Z
dc.identifier.citationBenli A., Tor Y. B., Simsek-Yavuz S., Basaran S., Cagatay A., Ozsut H., Gül A., Eraksoy H., "HIDDEN DANGER OF SARS-COV-2; MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS (MIS-A): FIRST CASE SERIES IN A SINGLE CENTER FROM TURKIYE", JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.85, ss.494-500, 2022
dc.identifier.issn1305-6441
dc.identifier.othervv_1032021
dc.identifier.otherav_293b0705-016f-4ef6-a2eb-c14d23e12b16
dc.identifier.urihttp://hdl.handle.net/20.500.12627/187267
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/293b0705-016f-4ef6-a2eb-c14d23e12b16/file
dc.identifier.urihttps://doi.org/10.26650/iuitfd.1136316
dc.description.abstractObjective: Multisystem Inflammatory Syndrome (MIS) is a con-dition seen in the early post-COVID-19 period and thought to develop with an impaired immune response. It has been usually reported in children but rarely in adults. Here we report the first MIS-A case series from Turkiye.Material and Methods: Six patients who met the Centers for Disease Control and Preventions MIS-A diagnostic criteria were included in the study. The demographic, clinical, laboratory, ra-diological characteristics and therapy regimes and outcomes of the patients were recorded.Results: All of our cases had a history of mild COVID-19. They presented with fever, severe fatigue and hypotension. Abnormal echocardiography findings were detected in five patients. Only one patient had multiple mucocutaneous findings. Common lab-oratory features were lymphopenia, markedly increased C-Reak-tive Protein, procalcitonin, pro-brain natriuretic peptide (pro-BNP), D-dimer, and ferritin. All patients had positive SARS-CoV-2 antibody result. Corticosteroids and/or anakinra were used in five, Intravenous immunoglobulin was used in two patients. Low-mo-lecular-weight heparin (LMWH) was used for all cases. Empirically initiated antibiotic treatments were discontinued after cultures were negative. After anti-inflammatory treatment, the hypoten-sion of the patients resolved, they did not need intensive care follow-up and no mortality was seen in our cases.Conclusions: MIS-A is a severe and mortal condition that causes various clinical pictures and can be confused with sepsis. Anakin-ra, a recombinant IL-1 receptor antagonist, is a significant agent that can be used in the treatment of MIS-A since it blocks the cytokine cascade at an early stage. The satisfactory respons-es will be obtained with early diagnosis and anti-inflammatory treatment. In this period when the pandemic is not over yet, it is necessary to increase the awareness of clinicians about MIS-A, which can be fatal.
dc.language.isoeng
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectTıp
dc.titleHIDDEN DANGER OF SARS-COV-2; MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS (MIS-A): FIRST CASE SERIES IN A SINGLE CENTER FROM TURKIYE
dc.typeMakale
dc.relation.journalJOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume85
dc.identifier.startpage494
dc.identifier.endpage500
dc.contributor.firstauthorID4070845


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