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dc.contributor.authorPereyra, Cecilia
dc.contributor.authorBlot, Stijn
dc.contributor.authorRello, Jordi
dc.contributor.authorPaiva, Jose Artur
dc.contributor.authorVogelaers, Dirk
dc.contributor.authorArvaniti, Kostoula
dc.contributor.authorDimopoulos, George
dc.contributor.authorAntonelli, Massimo
dc.contributor.authorBlot, Koen
dc.contributor.authorCreagh-Brown, Ben
dc.contributor.authorDeschepper, Mieke
dc.contributor.authorde Lange, Dylan
dc.contributor.authorDe Waele, Jan
dc.contributor.authorDİKMEN, YALIM
dc.contributor.authorEckmann, Christian
dc.contributor.authorEinav, Sharon
dc.contributor.authorFrancois, Guy
dc.contributor.authorFjeldsoee-Nielsen, Hans
dc.contributor.authorGirardis, Massimo
dc.contributor.authorJovanovic, Bojan
dc.contributor.authorLindner, Matthias
dc.contributor.authorKoulenti, Despoina
dc.contributor.authorLabeau, Sonia
dc.contributor.authorLipman, Jeffrey
dc.contributor.authorLipovestky, Fernando
dc.contributor.authorMakikado, Luis Daniel Umezawa
dc.contributor.authorMaseda, Emilio
dc.contributor.authorMikstacki, Adam
dc.contributor.authorMontravers, Philippe
dc.contributor.authorTomescu, Dana
dc.contributor.authorTimsit, Jean-Francois
dc.date.accessioned2023-02-21T10:03:44Z
dc.date.available2023-02-21T10:03:44Z
dc.date.issued2022
dc.identifier.citationArvaniti K., Dimopoulos G., Antonelli M., Blot K., Creagh-Brown B., Deschepper M., de Lange D., De Waele J., DİKMEN Y., Eckmann C., et al., "Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, cilt.60, sa.1, 2022
dc.identifier.issn0924-8579
dc.identifier.othervv_1032021
dc.identifier.otherav_3b610274-20a8-46c8-9445-f58c14859572
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188051
dc.identifier.urihttps://doi.org/10.1016/j.ijantimicag.2022.106591
dc.description.abstractObjective: To describe epidemiology and age-related mortality in critically ill older adults with intraabdominal infection.Methods: A secondary analysis was undertaken of a prospective, multi-national, observational study (Abdominal Sepsis Study, ClinicalTrials.gov #NCT03270345) including patients with intra-abdominal infection from 309 intensive care units (ICUs) in 42 countries between January and December 2016. Mortality was considered as ICU mortality, with a minimum of 28 days of observation when patients were discharged earlier. Relationships with mortality were assessed by logistic regression analysis.Results: The cohort included 2337 patients. Four age groups were defined: middle-aged patients [reference category; 40-59 years; n = 659 (28.2%)], young-old patients [60-69 years; n = 622 (26.6%)], middle old patients [70-79 years; n = 667 (28.5%)] and very old patients [ >80 years; n = 389 (16.6%)]. Secondary peritonitis was the predominant infection (68.7%) and was equally prevalent across age groups. Mortality increased with age: 20.9% in middle-aged patients, 30.5% in young-old patients, 31.2% in middle-old patients, and 44.7% in very old patients ( P 60 years was associated with mortality; patients aged >80 years had the worst prognosis. Comorbidities and overall disease severity further compromised survival. As all of these factors are non-modifiable, it remains unclear how to improve outcomes.(c) 2022 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
dc.language.isoeng
dc.subjectPharmacology (medical)
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectGeneral Immunology and Microbiology
dc.subjectPharmacology
dc.subjectImmunology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectHealth Sciences
dc.subjectLife Sciences
dc.subjectInfectious Diseases
dc.subjectDrug Guides
dc.subjectPharmacy
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.titleEpidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
dc.contributor.departmentPapageorgiou Univ , ,
dc.identifier.volume60
dc.identifier.issue1
dc.contributor.firstauthorID3435724


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