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dc.contributor.authorSolakoğlu, Seyhun
dc.contributor.authorYurdabakan, Zeliha Zuhal
dc.contributor.authorOzcan, Ilknur
dc.date.accessioned2023-02-21T10:29:48Z
dc.date.available2023-02-21T10:29:48Z
dc.date.issued2022
dc.identifier.citationYurdabakan Z. Z., Ozcan I., Solakoğlu S., "EFFECTS OF CHEMO-THERAPEUTIC DRUGS USED IN HEAD AND NECK CANCERS ON SUBMANDIBULAR GLANDS OF RATS", Journal of Stomatology, cilt.75, sa.2, ss.61-71, 2022
dc.identifier.issn0011-4553
dc.identifier.othervv_1032021
dc.identifier.otherav_458a2990-391c-48ca-8e71-47d459f73b04
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188454
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/458a2990-391c-48ca-8e71-47d459f73b04/file
dc.identifier.urihttps://doi.org/10.5114/jos.2022.117327
dc.description.abstract© 2022 Polish Dental AssociationIntroduction: Chemo-therapeutic drugs can cause morphological damages to the salivary glands. Objectives: This study aimed to analyze and elucidate 5-fluorouracil (5-FU), cisplatin, methotrexate (MTX), and adriamycin (ADR)-induced morphological changes on submandibular glands (SMGs) of the rats. Material and methods: Forty male Wistar albino rats were divided into five groups, with 8 rats per group. In the control group, 1 ml/kg 0.9% sterile saline solution; in the second group, 100 mg/kg dose of 5-FU; in the third group, 5 mg/kg dose of cisplatin; in the fourth group, 15 mg/kg dose of MTX; in the fifth group, 15 mg/kg dose of ADR were injected once a day for three consecutive days intra-peritoneally. In all groups, SMGs were excised, histopathological analyses were done using a light microscope, and total protein content was analyzed according to Lowry method. Data were examined using analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, and Dunn’s tests. Results were evaluated at 95% confidence interval and significance level of p 0.05). Acinus areas of 5-FU, ADR, cisplatin, and MTX groups were lower than that of the control significantly (p < 0.001). Conclusions: According to morphological parameters of our study, the most toxic effects were found to be caused by 5-FU, followed by ADR and cisplatin, while MTX presented the least toxic effects on the rats’ SMGs.
dc.language.isoeng
dc.subjectTıp
dc.subjectDiş Hekimliği
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectSağlık Bilimleri
dc.titleEFFECTS OF CHEMO-THERAPEUTIC DRUGS USED IN HEAD AND NECK CANCERS ON SUBMANDIBULAR GLANDS OF RATS
dc.typeMakale
dc.relation.journalJournal of Stomatology
dc.contributor.departmentİstanbul Üniversitesi , Diş Hekimliği Fakültesi , Klinik Bilimler Bölümü
dc.identifier.volume75
dc.identifier.issue2
dc.identifier.startpage61
dc.identifier.endpage71
dc.contributor.firstauthorID4203994


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