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dc.contributor.authorJuzar, Dafsah Arifa
dc.contributor.authorBrum Silveira, João António
dc.contributor.authorZoni, Cesar Rodrigo
dc.contributor.authorBessonov, Ivan
dc.contributor.authorUccello, Giuseppe
dc.contributor.authorKochiadakis, George
dc.contributor.authorAlexopulos, Dimitrios
dc.contributor.authorUribe, Carlos E.
dc.contributor.authorKanakakis, John
dc.contributor.authorFaurie, Benjamin
dc.contributor.authorGabrielli, Gabriele
dc.contributor.authorGutierrez Barrios, Alejandro
dc.contributor.authorBachini, Juan Pablo
dc.contributor.authorRocha, Alex
dc.contributor.authorTam, Frankie C. C.
dc.contributor.authorRodriguez, Alfredo
dc.contributor.authorLukito, Antonia Anna
dc.contributor.authorSaint-Joy, Veauthyelau
dc.contributor.authorPessah, Gustavo
dc.contributor.authorTuccillo, Andrea
dc.contributor.authorIelasi, Alfonso
dc.contributor.authorCortese, Giuliana
dc.contributor.authorParodi, Guido
dc.contributor.authorBurgadha, Mohammed Abed
dc.contributor.authorKedhi, Elvin
dc.contributor.authorLamelas, Pablo
dc.contributor.authorSuryapranata, Harry
dc.contributor.authorNardin, Matteo
dc.contributor.authorVerdoia, Monica
dc.contributor.authorDe Luca, Giuseppe
dc.contributor.authorAlgowhary, Magdy
dc.contributor.authorUguz, Berat
dc.contributor.authorOliveira, Dinaldo C.
dc.contributor.authorGanyukov, Vladimir
dc.contributor.authorBusljetik, Oliver
dc.contributor.authorCercek, Miha
dc.contributor.authorJensen, Lisette Okkels
dc.contributor.authorLoh, Poay Huan
dc.contributor.authorCalmac, Lucian
dc.contributor.authorFerrer, Gerard Roura i
dc.contributor.authorQuadros, Alexandre
dc.contributor.authorMilewski, Marek
dc.contributor.authorScotto D’Uccio, Fortunato
dc.contributor.authorvon Birgelen, Clemens
dc.contributor.authorVersaci, Francesco
dc.contributor.authorTen Berg, Jurrien
dc.contributor.authorCasella, Gianni
dc.contributor.authorWong Sung Lung, Aaron
dc.contributor.authorKala, Petr
dc.contributor.authorDíez Gil, José Luis
dc.contributor.authorCarrillo, Xavier
dc.contributor.authorDirksen, Maurits
dc.contributor.authorBecerra Munoz, Victor
dc.contributor.authorLee, Michael Kang-yin
dc.contributor.authorde Moura Joaquim, Rodrigo
dc.contributor.authorPaladino, Roberto
dc.contributor.authorMilicic, Davor
dc.contributor.authorDavlouros, Periklis
dc.contributor.authorBakraceski, Nikola
dc.contributor.authorZilio, Filippo
dc.contributor.authorDonazzan, Luca
dc.contributor.authorKraaijeveld, Adriaan
dc.contributor.authorGalasso, Gennaro
dc.contributor.authorArpad, Lux
dc.contributor.authorMarinucci, Lucia
dc.contributor.authorGuiducci, Vincenzo
dc.contributor.authorMenichelli, Maurizio
dc.contributor.authorScoccia, Alessandra
dc.contributor.authorYamac, Aylin Hatice
dc.contributor.authorUgur Mert, Kadir
dc.contributor.authorFlores Rios, Xacobe
dc.contributor.authorKovarnik, Tomas
dc.contributor.authorKidawa, Michal
dc.contributor.authorMoreu, Josè
dc.contributor.authorFlavien, Vincent
dc.contributor.authorFabris, Enrico
dc.contributor.authorMartínez-Luengas, Iñigo Lozano
dc.contributor.authorBoccalatte, Marco
dc.contributor.authorBosa Ojeda, Francisco
dc.contributor.authorArellano-Serrano, Carlos
dc.contributor.authorCaiazzo, Gianluca
dc.contributor.authorCirrincione, Giuseppe
dc.contributor.authorKao, Hsien-Li
dc.contributor.authorSanchis Forés, Juan
dc.contributor.authorVignali, Luigi
dc.contributor.authorPereira, Helder
dc.contributor.authorManzo-Silberman, Stephane
dc.contributor.authorOrdoñez, Santiago
dc.contributor.authorArat Özkan, Alev
dc.contributor.authorScheller, Bruno
dc.contributor.authorLehitola, Heidi
dc.contributor.authorTeles, Rui
dc.contributor.authorMantis, Christos
dc.contributor.authorAntti, Ylitalo
dc.date.accessioned2023-05-29T13:01:56Z
dc.date.available2023-05-29T13:01:56Z
dc.date.issued2023
dc.identifier.citationDe Luca G., Algowhary M., Uguz B., Oliveira D. C., Ganyukov V., Busljetik O., Cercek M., Jensen L. O., Loh P. H., Calmac L., et al., "Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry", Journal of Clinical Medicine, cilt.12, sa.6, 2023
dc.identifier.issn2077-0383
dc.identifier.othervv_1032021
dc.identifier.otherav_294780c3-7df1-448e-a83c-1b149be0f35b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188955
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/294780c3-7df1-448e-a83c-1b149be0f35b/file
dc.identifier.urihttps://doi.org/10.3390/jcm12062116
dc.description.abstractBackground: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectGenel Tıp
dc.subjectTıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTemel Tıp Bilimleri
dc.titleAge-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
dc.typeMakale
dc.relation.journalJournal of Clinical Medicine
dc.contributor.departmentUniversità degli Studi di Messina, Facoltà di Medicina e Chirurgia , ,
dc.identifier.volume12
dc.identifier.issue6
dc.contributor.firstauthorID4270450


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