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dc.contributor.authorIyibozkurt, Ahmet Cem
dc.contributor.authorÇAKMAKOĞLU, Bedia
dc.contributor.authorBİRELLER, ELİF SİNEM
dc.contributor.authorERTUĞRUL, Barış
dc.date.accessioned2023-10-10T10:14:53Z
dc.date.available2023-10-10T10:14:53Z
dc.date.issued2022
dc.identifier.citationIyibozkurt A. C., ERTUĞRUL B., BİRELLER E. S., ÇAKMAKOĞLU B., "NF-k(1)B and COX-2 Relation Between Endometrial Cancer and the Clinicopathological Parameters", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, sa.4, ss.1025-1031, 2022
dc.identifier.issn2459-1459
dc.identifier.othervv_1032021
dc.identifier.otherav_00203908-61b9-439f-b9c8-d4ccf1398eae
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189119
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1049382
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/00203908-61b9-439f-b9c8-d4ccf1398eae/file
dc.description.abstractObjective: Our study examines nuclear factor kappa B (NF-.B) and cyclooxygenase-2 (COX-2) polymorphisms in the most common gynecological cancer type, endometrial cancer, and the relationship between disease parameters and these polymorphisms. Methods: In our patient group; while 109 endometrial cancer patients were examined and treated in the Department of Gynecology and Obstetrics, Istanbul Medical Faculty, and 106 healthy women without the disease were included in the control group. DNA of blood samples taken from all groups were isolated; COX-2 765C> G and COX-2 1195A> G polymorphisms were studied with NF-.B-94 ins / delATTG. Genotypes analyzed using the PCR-based restriction fragment length polymorphisms (RFLP) method were investigated in terms of the relationship between endometrial cancer susceptibility and endometrial cancer disease parameters. Results in SPSS 17 program; Student's t-tests were analyzed using Anova, Fisher's exact, and Chi-square tests. Results: NF-.B D + and DD genotype, COX-2 765 G + and GG genotype, and COX-2 1195 AA genotype were found to be significantly more common in the endometrial cancer group compared to the control group (p <0.05). However, no significant relationship was found between polymorphisms and disease parameters. Conclusion: NF-.B and COX-2 polymorphisms are more common in women with endometrial cancer. However, the absence of a link between these polymorphisms and the prevalence or violence of the disease suggests that they often trigger cancer development.
dc.language.isoeng
dc.subjectİncelemeler ve Referanslar (tıbbi)
dc.subjectSağlık Bilimleri
dc.subjectAraştırma ve Teori
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.titleNF-k(1)B and COX-2 Relation Between Endometrial Cancer and the Clinicopathological Parameters
dc.typeMakale
dc.relation.journalCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.identifier.issue4
dc.identifier.startpage1025
dc.identifier.endpage1031
dc.contributor.firstauthorID4312326


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