NF-k(1)B and COX-2 Relation Between Endometrial Cancer and the Clinicopathological Parameters

Abstract

Objective: Our study examines nuclear factor kappa B (NF-.B) and cyclooxygenase-2 (COX-2) polymorphisms in the most common gynecological cancer type, endometrial cancer, and the relationship between disease parameters and these polymorphisms. Methods: In our patient group; while 109 endometrial cancer patients were examined and treated in the Department of Gynecology and Obstetrics, Istanbul Medical Faculty, and 106 healthy women without the disease were included in the control group. DNA of blood samples taken from all groups were isolated; COX-2 765C> G and COX-2 1195A> G polymorphisms were studied with NF-.B-94 ins / delATTG. Genotypes analyzed using the PCR-based restriction fragment length polymorphisms (RFLP) method were investigated in terms of the relationship between endometrial cancer susceptibility and endometrial cancer disease parameters. Results in SPSS 17 program; Student's t-tests were analyzed using Anova, Fisher's exact, and Chi-square tests. Results: NF-.B D + and DD genotype, COX-2 765 G + and GG genotype, and COX-2 1195 AA genotype were found to be significantly more common in the endometrial cancer group compared to the control group (p <0.05). However, no significant relationship was found between polymorphisms and disease parameters. Conclusion: NF-.B and COX-2 polymorphisms are more common in women with endometrial cancer. However, the absence of a link between these polymorphisms and the prevalence or violence of the disease suggests that they often trigger cancer development.