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dc.contributor.authorKaramustafalioglu, Nesrin
dc.contributor.authorCihnioglu, Refik
dc.contributor.authorKalelioglu, Tevfik
dc.contributor.authorOzpercin, Pelin Unalan
dc.contributor.authorOksuz, Ozge Yuksel
dc.contributor.authorSozen, Sule
dc.contributor.authorKendirlioglu, Burcu Kok
dc.date.accessioned2023-10-10T11:21:51Z
dc.date.available2023-10-10T11:21:51Z
dc.date.issued2023
dc.identifier.citationKendirlioglu B. K., Cihnioglu R., Kalelioglu T., Ozpercin P. U., Oksuz O. Y., Sozen S., Karamustafalioglu N., "MAY PPAR GAMMA BE SIGNIFICANT IN BIPOLAR DISORDER ONLY IN THE PRESENCE OF METABOLIC SYNDROME?", Psychiatria Danubina, cilt.35, sa.2, ss.210-219, 2023
dc.identifier.issn0353-5053
dc.identifier.othervv_1032021
dc.identifier.otherav_125ef8b9-1646-4462-96ae-9ffeffc0a018
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189689
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/125ef8b9-1646-4462-96ae-9ffeffc0a018/file
dc.identifier.urihttps://doi.org/10.24869/psyd.2023.210
dc.description.abstractBackground: Peroxisome proliferator-activated receptor γ (PPARγ) has a key role in regulating both neurogenesis and various metabolic processes, including adipogenesis and glucose homeostasis. In this study, it was aimed to compare the serum PPARγ levels and metabolic syndrome (MetS) parametres of patients with Bipolar Disorder (BD) diagnosed manic-depressive-euthymic episodes with those of healthy subjects. Subjects and Methods: We included 121 male patients with BD type I, 44 in mania, 35 in depression and 42 in euthymic state, and 41 healthy controls. Serum PPARγ levels, inflammation indicators (CRP, neutrophil, leukocyte, and albumin) and Mets parametres were measured. Results: There were no statistically significant differences between the groups in terms of PPARγ values. PPARγ serum level is highest in the control group and then euthymic, manic and depressive episodes continue to decrease, respectively. However, there was a significant difference between the depressive group with MetS and without MetS in terms of serum PPARγ levels. A statistically significant correlation was found between PPARγ and the other serum markers such as low-density lipoprotein (p=0.022), HbA1c (p=0.002), neutrophils levels (0.001), white blood cell (p=0.025), and clinical features such as age at first treatment (p=0.024), age at first episode (p=0.039), and smoking (0.013). Conclusions: We suggest that PPARγ may be a key factor in the BD depressive group with MetS. Not finding any relationship between the PPARγ levels and the episode of BD may be related with the absence of MetS in the individuals. MetS parametres must also be considered if PPARγ is to be evaluated in the future investigations.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectTemel Tıp Bilimleri
dc.subjectGenel Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.titleMAY PPAR GAMMA BE SIGNIFICANT IN BIPOLAR DISORDER ONLY IN THE PRESENCE OF METABOLIC SYNDROME?
dc.typeMakale
dc.relation.journalPsychiatria Danubina
dc.contributor.departmentT.C. Maltepe Universitesi Tip Fakültesi , ,
dc.identifier.volume35
dc.identifier.issue2
dc.identifier.startpage210
dc.identifier.endpage219
dc.contributor.firstauthorID4514662


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