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dc.contributor.authorSakin, Nergiz Dagoglu
dc.contributor.authorKaraman, Sule
dc.contributor.authorGÖKSEL, Evren Ozan
dc.contributor.authorOkutan, Murat
dc.contributor.authorBarburoglu, Mehmet
dc.contributor.authorKuru, Gulcin
dc.date.accessioned2023-10-10T11:24:01Z
dc.date.available2023-10-10T11:24:01Z
dc.identifier.citationKuru G., GÖKSEL E. O., Sakin N. D., Karaman S., Barburoglu M., Okutan M., "Hippocampal Sparing in Stereotactic Radiotherapy for Multiple Brain Metastases: A Comparison of Intensity-modulated Arc Therapy, CyberKnife, and Helical Radiotherapy", TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, 2023
dc.identifier.issn1300-7467
dc.identifier.othervv_1032021
dc.identifier.otherav_1351619f-74fd-4350-8142-ffe07c1501fb
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189710
dc.identifier.urihttps://doi.org/10.5505/tjo.2023.3980
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/1351619f-74fd-4350-8142-ffe07c1501fb/file
dc.description.abstractOBJECTIVE In this study, we performed a plan study to evaluate brain and hippocampal doses with hippocampal sparing in the treatment of multiple brain metastases with stereotactic radiosurgery (SRS). For this purpose, treatment plans prepared using intensity-modulated arc therapy (IMAT), CyberKnife radio surgery, and helical tomotherapy techniques. The results were compared and evaluated according to their superiority to each other.METHODS Fifteen patients with multiple brain metastases who had a tumor diameter of <3.5 cm were included in this study. IMAT, CK, and HT plans were separately created for each patient. The dose prescription was defined as 18 Gy in the single fraction.RESULTS The D40% of hippocampal (in Gy) averaged 1.63, 1.69, and 0.52 for IMAT, CyberKnife, and Tomotherapy, respectively. The median hippocampal Dmax (in Gy) averaged 2.81, 4.63, and 1.98, respectively. Some plans were statically different in terms of critical organ doses, but the results were clinically acceptable. The mean values of V12 (cc) were found to be 12.6, 38.23, and 37.46 for IMAT, CyberKnife, and Tomotherapy, respectively, when evaluating the doses taken by healthy brain tissue.CONCLUSION Brain radiotherapy is a treatment modality for primary and metastatic lesions. However, after radiotherapy (even with SRS) damage especially in the hippocampus may cause cognitive impairment and a decrease in patients' quality of life. Therefore, when the hippocampus is outlined as organs of risk, it can be protected without compromising PTV coverage. We saw this result in all of three treatment platforms used in this study.
dc.language.isoeng
dc.subjectOnkoloji
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.subjectİç Hastalıkları
dc.titleHippocampal Sparing in Stereotactic Radiotherapy for Multiple Brain Metastases: A Comparison of Intensity-modulated Arc Therapy, CyberKnife, and Helical Radiotherapy
dc.typeMakale
dc.relation.journalTURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
dc.contributor.departmentİstanbul Teknik Üniversitesi , ,
dc.contributor.firstauthorID4314661


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