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dc.contributor.authorSinani, Genada
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorÖzsoy, Yıldız
dc.contributor.authorCEVHER, Erdal
dc.date.accessioned2023-10-10T11:24:50Z
dc.date.available2023-10-10T11:24:50Z
dc.date.issued2023
dc.identifier.citationSinani G., Durgun M. E., CEVHER E., Özsoy Y., "Polymeric-Micelle-Based Delivery Systems for Nucleic Acids", Pharmaceutics, cilt.15, sa.8, 2023
dc.identifier.issn1999-4923
dc.identifier.othervv_1032021
dc.identifier.otherav_136d96d1-22bb-48be-941d-e1aa6cdba30c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189712
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168797305&origin=inward
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics15082021
dc.description.abstractNucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTROPİKAL TIP
dc.subjectSağlık Bilimleri
dc.subjectFarmasötik bilim
dc.subjectYaşam Bilimleri
dc.subjectTıp
dc.titlePolymeric-Micelle-Based Delivery Systems for Nucleic Acids
dc.typeMakale
dc.relation.journalPharmaceutics
dc.contributor.departmentAltinbas Universitesi , ,
dc.identifier.volume15
dc.identifier.issue8
dc.contributor.firstauthorID4523586


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