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dc.contributor.authorKizilates-Evin, Gozde
dc.contributor.authorDEMİRALP, Tamer
dc.contributor.authorGurvit, Hakan
dc.contributor.authorKURT, Elif
dc.contributor.authorULAŞOĞLU YILDIZ, ÇİĞDEM
dc.contributor.authorHari, Emre
dc.contributor.authorBAYRAM, Ali
dc.date.accessioned2023-10-10T12:24:54Z
dc.date.available2023-10-10T12:24:54Z
dc.identifier.citationHari E., Kizilates-Evin G., KURT E., BAYRAM A., ULAŞOĞLU YILDIZ Ç., Gurvit H., DEMİRALP T., "Functional and structural connectivity in the Papez circuit in different stages of Alzheimer's disease", Clinical Neurophysiology, cilt.153, ss.33-45, 2023
dc.identifier.issn1388-2457
dc.identifier.othervv_1032021
dc.identifier.otherav_1fc85d74-eb4a-47ca-9f68-9c7c294c598e
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190067
dc.identifier.urihttps://doi.org/10.1016/j.clinph.2023.06.008
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164747222&origin=inward
dc.description.abstractObjective: Alzheimer's disease (AD) is a progressive neurodegenerative continuum with memory impairment. We aimed to examine the detailed functional (FC) and structural connectivity (SC) pattern of the Papez circuit, known as the memory circuit, along the AD. Methods: MRI data of 15 patients diagnosed with AD dementia (ADD), 15 patients with the amnestic mild cognitive impairment (MCI), and 15 patients with subjective cognitive impairment were analyzed. The FC analyses were performed between main nodes of the Papez circuit, and the SC was quantified as fractional anisotropy (FA) of the main white matter pathways of the Papez circuit. Results: The FC between the retrosplenial (RSC) and parahippocampal cortices (PHC) was the earliest affected FC, while a manifest SC change in the ventral cingulum and fornix was observed in the later ADD stage. The RSC-PHC FC and the ventral cingulum FA efficiently predicted the memory performance of the non-demented participants. Conclusions: Our findings revealed the importance of the Papez circuit as target regions along the AD. Significance: The ventral cingulum connecting the RSC and PHC, a critical overlap area between the Papez circuit and the default mode network, seems to be a target region associated with the earliest objective memory findings in AD.
dc.language.isoeng
dc.subjectNöroloji (klinik)
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectSinirbilim ve Davranış
dc.subjectBiyoloji ve Biyokimya
dc.subjectFİZYOLOJİ
dc.subjectSİNİR BİLİMİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectFizyoloji
dc.subjectTemel Bilimler
dc.subjectDuyusal Sistemler
dc.subjectFizyoloji (tıbbi)
dc.titleFunctional and structural connectivity in the Papez circuit in different stages of Alzheimer's disease
dc.typeMakale
dc.relation.journalClinical Neurophysiology
dc.contributor.departmentİstanbul Üniversitesi , Aziz Sancar Deneysel Tıp Araştırma Enstitüsü , Sinir Bilimi Ana Bilim Dalı
dc.identifier.volume153
dc.identifier.startpage33
dc.identifier.endpage45
dc.contributor.firstauthorID4350135


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