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dc.contributor.authorDOĞAN, CEZMİ
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorBAHAR TOKMAN, HRİSİ
dc.contributor.authorARSLAN, OSMAN ŞEVKİ
dc.contributor.authorKOCAZEYBEK, BEKİR SAMİ
dc.contributor.authorSARIBAŞ, ABDULKERİM SUAT
dc.contributor.authorAkcin, Rueveyda
dc.contributor.authorDİNÇ, HARİKA ÖYKÜ
dc.contributor.authorSavaser, Selva
dc.contributor.authorOzbey, Dogukan
dc.date.accessioned2023-10-10T12:34:50Z
dc.date.available2023-10-10T12:34:50Z
dc.date.issued2022
dc.identifier.citationAkcin R., DİNÇ H. Ö., Savaser S., Ozbey D., DOĞAN C., Demirci M., BAHAR TOKMAN H., SARIBAŞ A. S., ARSLAN O. Ş., KOCAZEYBEK B. S., "Serological and Molecular Tests Performed Pre-Transplantation on Post-Mortem Cornea Donors: Retrospective Evaluation of 5-Years", KLIMIK JOURNAL, sa.2, ss.103-108, 2022
dc.identifier.issn1301-143X
dc.identifier.otherav_2391579a-c714-47d7-acb4-4c04d1da0689
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190174
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/2391579a-c714-47d7-acb4-4c04d1da0689/file
dc.identifier.urihttps://doi.org/10.36519/kd.2022.3941
dc.description.abstractObjective: Control of corneal damage with endothelial cell count and serological screening before keratoplasty are critical issues for recipient health. We aimed to detect the pre-transplantation hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Treponema pallidum serological test results of post-mortem corneal donors and to determine their correlation with serological and molecular tests to support or verify low reactive/positive test results.Methods: The serological test results of post-mortem corneal donors sent from the eye bank between January 2015 and December 2020 were analyzed retrospectively, and demographic and serological test data of these donors were obtained from ELISA laboratory data by the ISHOP system Cerrahpaca Medical Faculty Hospital.Results: Of 424 post-mortem corneal donors, 161 (37.7%) were female, and 263 (62.03) were male; 13 (3.06%) had high HBsAg positivity, 23 (5.42%) had low anti-HCV reactivity, 19 (4.48%) had low anti-HIV 1/2 reactivity, and two (0.47%) had high Tp-Ab IgG reactivity. Therefore, the corneas of a 30-year-old woman with positive HCV RNA result and 13 donors with high titer HBsAg positivity, and two donors with high reactivity in the Tp-Ab IgG test were not eligible for the Eye Bank after performing a real-time PCR assay for the confirmation of donors with low reactivity.Conclusion: We believe that it is essential to apply serological tests pre-keratoplasty to prevent infection transmission and perform confirmatory tests in low positivity/reactivity that may occur due to post-mortem coagulum hemolysis, within the framework of a collective and specific algorithm.
dc.language.isoeng
dc.subjectTıp (çeşitli)
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTemel Bilimler
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectGenel Tıp
dc.titleSerological and Molecular Tests Performed Pre-Transplantation on Post-Mortem Cornea Donors: Retrospective Evaluation of 5-Years
dc.typeMakale
dc.relation.journalKLIMIK JOURNAL
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , Cerrahpaşa Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.issue2
dc.identifier.startpage103
dc.identifier.endpage108
dc.contributor.firstauthorID4312102


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