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dc.contributor.authorZhao, Zuotao
dc.contributor.authorSalameh, Pascale
dc.contributor.authorGonçalo, Margarida
dc.contributor.authorAltrichter, Sabine
dc.contributor.authorKhoshkhui, Maryam
dc.contributor.authorMetz, Martin
dc.contributor.authorNasr, Iman
dc.contributor.authorSteć, Michał
dc.contributor.authorAulenbacher, Felix
dc.contributor.authorGelincik Akkor, Aslı
dc.contributor.authorBonnekoh, Hanna
dc.contributor.authorJelden-Thurm, Jannis
dc.contributor.authorAllenova, Anastasiia
dc.contributor.authorChen, Yudi
dc.contributor.authorCherrez-Ojeda, Ivan
dc.contributor.authorDanilycheva, Inna
dc.contributor.authorDorofeeva, Irina
dc.contributor.authorJardim Criado, Roberta Fachini
dc.contributor.authorCriado, Paulo Ricardo
dc.contributor.authorHawro, Tomasz
dc.contributor.authorKocatürk, Emek
dc.contributor.authorKolkhir, Pavel
dc.contributor.authorKrause, Karoline
dc.contributor.authorMaurer, Marcus
dc.contributor.authorGimenez-Arnau, Ana
dc.date.accessioned2023-10-10T12:48:23Z
dc.date.available2023-10-10T12:48:23Z
dc.date.issued2023
dc.identifier.citationBonnekoh H., Jelden-Thurm J., Allenova A., Chen Y., Cherrez-Ojeda I., Danilycheva I., Dorofeeva I., Jardim Criado R. F., Criado P. R., Gelincik Akkor A., et al., "Urticarial Vasculitis Differs from Chronic Spontaneous Urticaria in Time to Diagnosis, Clinical Presentation, and Need for Anti-Inflammatory Treatment: An International Prospective UCARE Study.", The journal of allergy and clinical immunology. In practice, cilt.11, sa.9, ss.2900, 2023
dc.identifier.othervv_1032021
dc.identifier.otherav_2661bd82-a494-4b0e-940c-706dcade355c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190261
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85165002433&origin=inward
dc.identifier.urihttps://doi.org/10.1016/j.jaip.2023.06.030
dc.description.abstractBackground: Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) share several clinical features including the occurrence of wheals. As of yet, the criteria for differentiating the 2 disorders are not clearly defined. Objective: Here, we aimed to identify differences, similarities, and the likelihood for specific clinical features in patients with UV versus those with CSU. Methods: Across 10 Urticaria Centers of Reference and Excellence, 106 patients with skin biopsy–confirmed UV and 126 patients with CSU were prospectively recruited to complete a questionnaire on the clinical features, course, and response to treatment of their disease. Results: As compared with CSU, patients with UV more often experienced postinflammatory skin hyperpigmentation, wheals of ≥24-hour duration, eye inflammation, and fever (6.9, 4.0, 3.6, and 2.4 times, respectively). Clinical features that increased the risk for UV diagnosis when present at the onset of disease included wheals of ≥24-hour duration (7.3-fold), pain of the skin (7.0-fold), postinflammatory hyperpigmentation (4.1-fold), and fatigue (3.1-fold). The diagnostic delay was markedly longer for normocomplementemic UV as compared with hypocomplementemic UV and CSU (21 vs 5 vs 6 months, respectively). Oral corticosteroids and omalizumab were the most effective treatments in patients with UV and CSU, respectively. Patients with UV showed a higher need for immunosuppressive and anti-inflammatory therapies than patients with CSU. Conclusions: Long wheal duration, skin pain and hyperpigmentation, and systemic symptoms point to UV rather than CSU as the underlying disease and should prompt further diagnostic workup including a skin biopsy.
dc.language.isoeng
dc.subjectALERJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectİmmünoloji ve Alerji
dc.titleUrticarial Vasculitis Differs from Chronic Spontaneous Urticaria in Time to Diagnosis, Clinical Presentation, and Need for Anti-Inflammatory Treatment: An International Prospective UCARE Study.
dc.typeMakale
dc.relation.journalThe journal of allergy and clinical immunology. In practice
dc.contributor.departmentBerliner Institut für Gesundheitsforschung , ,
dc.identifier.volume11
dc.identifier.issue9
dc.identifier.startpage2900
dc.identifier.endpage2900
dc.contributor.firstauthorID4403259


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