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dc.contributor.authorPeker, Barış
dc.contributor.authorDağdeviren, Hüseyin Emre
dc.contributor.authorÖzata, Musa Samet
dc.contributor.authorAydoseli, Aydın
dc.contributor.authorSencer, Altay
dc.contributor.authorÖztürk, Metehan
dc.contributor.authorDolaş, İlyas
dc.date.accessioned2023-10-10T12:49:35Z
dc.date.available2023-10-10T12:49:35Z
dc.identifier.citationÖztürk M., Dolaş İ., Özata M. S., Peker B., Dağdeviren H. E., Aydoseli A., Sencer A., "A single-center experience of transsphenoidal endoscopic surgery for acromegaly in 73 patients: results and predictive factors for remission", EANS 2021, 3 - 07 Temmuz 2021, ss.76
dc.identifier.othervv_1032021
dc.identifier.otherav_26d8a350-28a1-41e0-a8dd-3eaa3cef0151
dc.identifier.urihttp://hdl.handle.net/20.500.12627/190281
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2772529421005750
dc.description.abstractBackground: Transsphenoidal endoscopic surgery is the first-line treatment forgrowth hormone-secreting adenomas. The aim of the study is to analyze theresults of transsphenoidal endoscopic approach for acromegaly and to determinethe predictive factors for remission.Methods: A single-center retrospective review was performed in patients whounderwent endoscopic transsphenoidal surgery for acromegaly between January2009 and January 2019. Demographic features, clinical presentation, histopathologyrecords, postoperative complications, pre- and postoperative radiologic,and endocrinological assessments were evaluated. The factors that influence theremission rates were investigated.Results: A total of 73 patients were operated via transsphenoidal endoscopicapproach. Cavernous sinus invasion was detected in 32 (43,8%) patients and57 (78%) patients had macroadenomas. Pathology specimens of the 27(36,9%) patients revealed dual staining adenomas with prolactin. A total of51 patients (69,8%) were in biochemical remission one year after surgery. Asecond operation was performed in 10 patients (13,6%) with residual tumorand without biochemical remission in the first year. 6 of these patients (60%)were in remission at the last follow-up. Transient diabetes insipidus wasobserved in 18 (24,6%) patients and rhinorrhea in 4 patients (5,4%) whichceased with conservative treatment. None of the patients had developedpanhypopituitarism. The presence of cavernous sinus invasion, preoperativeIGF-1, immediate postoperative GH, and 3 rd -month IGF-1 levels are predictivefor remission.Conclusion: Transsphenoidal endoscopic surgery is a safe and effective treatmentfor acromegaly. Reoperation should be considered in patients with residualtumor and without remission.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectCerrahi
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSinir Sistemi Cerrahisi
dc.subjectTıp
dc.subjectCERRAHİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.titleA single-center experience of transsphenoidal endoscopic surgery for acromegaly in 73 patients: results and predictive factors for remission
dc.typeBildiri
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.contributor.firstauthorID4514823


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