dc.contributor.author | Kurtan, U. | |
dc.contributor.author | Alpsoy, L. | |
dc.contributor.author | Baykal, A. | |
dc.contributor.author | Akal, Z. U. | |
dc.date.accessioned | 2021-03-03T07:57:33Z | |
dc.date.available | 2021-03-03T07:57:33Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Alpsoy L., Baykal A., Kurtan U., Akal Z. U. , "Superparamagnetic Iron Oxide Nanoparticles (SPION) Functionalized by Caffeic Acid (CFA)", JOURNAL OF SUPERCONDUCTIVITY AND NOVEL MAGNETISM, cilt.30, sa.9, ss.2699-2706, 2017 | |
dc.identifier.issn | 1557-1939 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_14d54b55-81ab-478f-b6cd-239a24b34dcf | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/19382 | |
dc.identifier.uri | https://doi.org/10.1007/s10948-017-4088-3 | |
dc.description.abstract | In this research, we synthesized a novel caffeic acid-functionalized iron oxide nanoparticles (CFA-functionalized SPION) L929 (mouse fibroblast cell), U87 (glioblastoma brain cancer cell), MCF-7 (breast cancer cell), HeLa (cervix cancer cell), and A549 (human lung cancer cell) cell lines. Thermal decomposition and Stober methods were used to prepare APTES-capped SPION, respectively. The carboxylated polyethylene glycol (PEG-COOH), folic acid (FA), and caffeic acid (CFA) were attached to the surface of SPION via carboxylic/amine groups. Structural analysis (Rietveld analysis) confirmed the phase purity of the product. The conjugation of organics to the surface of SPION was followed with FT-IR spectroscopy and thermal gravimetric analysis (TGA). SEM analysis presented the spherical morphology of product with 13 +/- 3 nm particle size. And also, superparamagnetic property of product was deduced from VSM analysis. Uptake of CFA-functionalized SPION from the cell and release of CFA from CFA-functionalized SPION has been studied by using Prussian blue staining and spectrophotometer, respectively. Also, cell viability and cytotoxicity was tested by MTT and LDH assays. The uptake of CFA-functionalized SPION by HeLa, MCF-7, and U87 was higher than A549 and L929 cells. Also, caffeic acid release from CFA-functionalized SPION increased at an acidic environment (pH 4.4). A newly synthesized CFA-functionalized SPION in all used concentrations decreased cell viability and increased cytotoxicity at 24th and 48th hours. The results showed that the CFA-functionalized SPION is a potential anticancer agent for cancer therapy. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Fizik | |
dc.subject | FİZİK, UYGULAMALI | |
dc.subject | FİZİK, YOĞUN MADDE | |
dc.subject | Yoğun Madde 1:Yapısal, Mekanik ve Termal Özellikler | |
dc.subject | Temel Bilimler | |
dc.title | Superparamagnetic Iron Oxide Nanoparticles (SPION) Functionalized by Caffeic Acid (CFA) | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF SUPERCONDUCTIVITY AND NOVEL MAGNETISM | |
dc.contributor.department | Gama Mechatron Co 16159 , , | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 2699 | |
dc.identifier.endpage | 2706 | |
dc.contributor.firstauthorID | 245486 | |