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Effect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients

dc.contributor.authorBakkaloglu, H.
dc.contributor.authorTurkmen, A.
dc.contributor.authorGuney, I.
dc.contributor.authorNane, I.
dc.contributor.authorAydın, Ali Fuat
dc.contributor.authorGurtekin, M.
dc.contributor.authorCiftci, H. S.
dc.contributor.authorAyna, T. K.
dc.contributor.authorCaliskan, Y. K.
dc.date.accessioned2021-03-03T09:57:21Z
dc.date.available2021-03-03T09:57:21Z
dc.identifier.citationCiftci H. S. , Ayna T. K. , Caliskan Y. K. , Guney I., Bakkaloglu H., Nane I., Aydın A. F. , Turkmen A., Gurtekin M., "Effect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients", TRANSPLANTATION PROCEEDINGS, cilt.45, ss.895-900, 2013
dc.identifier.issn0041-1345
dc.identifier.othervv_1032021
dc.identifier.otherav_1fd2a826-93e6-4d2a-b76a-e2d836c04d06
dc.identifier.urihttp://hdl.handle.net/20.500.12627/26488
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2013.02.055
dc.description.abstractBackground. Tacrolimus, a calcineurin inhibitor, is prescribed to prevent allograft rejection in renal transplantation. Tacrolimus not only has a narrow therapeutic index, but also shows significant interindividual differences. The absorption and metabolism of this drug are affected by multidrug resistance (MDR) 1 gene polymorphisms that correlated with single-nucleotide polymorphisms (SNPs) affecting in vivo P-glycoprotein activity. This study investigated associations of MDR1 gene C3435T polymorphism with tacrolimus blood concentrations and dose requirements as well as acute rejection episodes among Turkish renal transplant patients.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTRANSPLANTASYON
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.titleEffect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients
dc.typeMakale
dc.relation.journalTRANSPLANTATION PROCEEDINGS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume45
dc.identifier.startpage895
dc.identifier.endpage900
dc.contributor.firstauthorID2484463


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